生命科学研究2017，Vol.21Issue(1)：10-15,6.DOI:10.16605/j.cnki.1007-7847.2017.01.003
CD4-CCR5工程类重组二价抗体的慢病毒包装及制备
Lentivirus Packaging and Preparation of CD4-CCR5 Recombinant Antibody
摘要
Abstract
The human immunodeficiency virus (HIV) has a close connection with CD4 and CCR5 molecules.In order to develop a recombinant drug which can specifically bind to the HIV and can effectively prevent and treat HIV infection,the heavy chain constant region of human IgG was connected with CD4 and the light chain constant region of human IgG was connected with CCR5.The cell lines stably expressing both chains were screened following constructed lentivirus co-infection.The recombinant antibody was proved to have anti-HIV function by molecular biology and cellular immunology tests,and may have clinical values in HIV studies.关键词
人类免疫缺陷病毒(HIV)/CD4/CCR5/重组抗体/慢病毒/蛋白质表达Key words
human immunodeficiency virus (HIV)/CD4/CCR5/recombinant antibody/lentivirus/protein expression分类
生物科学引用本文复制引用
易俊波,毛新,买制刚,李凌云,周兆平,苏庆宁..CD4-CCR5工程类重组二价抗体的慢病毒包装及制备[J].生命科学研究,2017,21(1):10-15,6.基金项目
深圳市自主创新生物产品研发资助计划项目(003646) （003646）
