生命科学研究2017，Vol.21Issue(1)：55-58,94,5.DOI:10.16605/j.cnki.1007-7847.2017.01.011
β-榄香烯诱导人黑色素瘤A375细胞凋亡的研究
Effect of β-elemene on Apoptosis in Human Melanoma A375 Cells
摘要
Abstract
β-elemene,a self-developed anticancer medicine in China,has an obvious therapeutic effect on liver cancer,lung cancer and other malignant tumors due to low toxicity,high efficacy and wide-spectrum activity,while its role on human skin cancer has not been reported.Here,the anti-tumor activity of β-elemene was investigated on human melanoma cells.It was found that the proliferation of A375 cells was significantly inhibited byβ-elemene (P＜0.01) in a concentration-and time-dependent manner.Furthermore,related apoptosis proteins were detected by Western-blot,which showed that β-elemene inhibited AKT signal pathway to regulate Bcl-2 family proteins.It reduced the expression of Bcl-2,but significantly increased the expression of Bad,and in the meantime partially activated caspase proteins,thereby inhibiting A375 cell proliferation and inducing apoptosis.关键词
β-榄香烯/抗肿瘤药物/人黑色素瘤细胞/细胞凋亡/信号机制Key words
β-elemene/anticancer medicine/human melanoma cells/cell apoptosis/signaling mechanism分类
医药卫生引用本文复制引用
蒋革,吴艳华,罗锋,薛勇,李清..β-榄香烯诱导人黑色素瘤A375细胞凋亡的研究[J].生命科学研究,2017,21(1):55-58,94,5.基金项目
辽宁省教育厅科学研究一般项目(L2014494) （L2014494）
