生命科学研究2017，Vol.21Issue(1)：85-94,10.DOI:10.16605/j.cnki.1007-7847.2017.01.016
作用于烟碱乙酰胆碱受体的α*-芋螺毒素研究进展
α*-Conotoxins Targeting Nicotinic Acetylcholine Receptors
摘要
Abstract
Conotoxins (CTxs) are a group of active peptides from Conus,the tropical marine mollusc.These peptides,with low relative molecular mass,target various ion channels and receptors in animals,and have great potential to be developed into novel drugs.Alpha-conotoxins (α-CTxs) are the earliest known and most important members that specifically act on the nicotinic acetylcholine receptors (nAChRs).They belong to the A-superfamily conotoxins and are selective blockers for muscle or nerve type nAChRs.The nAChRs are closely related with many central nervous system disorders,such as pain,addiction and cancer etc.Recently,other members from other superfamilies are also found to block nAChRs,such as αA-,αB-,αO-,αC-,αD-,and αS-superfamily conotoxins,and they are named α*-CTxs.Here,the progress of structure and function characteristics of α*-CTxs and the receptors,as well as their interactions,were reviewed,which would provide reference for relative research.关键词
生物活性肽/α*-芋螺毒素(α*-CTx)/烟碱型乙酰胆碱受体(nAChR)/构效关系Key words
bioactive peptide/α*-conotoxin (α*-CTx)/nicotinic acetylcholine receptor (nAChR)/structure/function relationship分类
医药卫生引用本文复制引用
徐盼,吴勇,邴晖,长孙东亭,罗素兰..作用于烟碱乙酰胆碱受体的α*-芋螺毒素研究进展[J].生命科学研究,2017,21(1):85-94,10.基金项目
国家自然科学基金资助项目(81420108028,41366002,81660585) （81420108028,41366002,81660585）
海南省重大科技计划项目(ZDKJ2016002) （ZDKJ2016002）
长江学者和创新团队发展计划(IRT_15R15) （IRT_15R15）
