山西医科大学学报2017，Vol.48Issue(3)：266-271,6.DOI:10.13753/j.issn.1007-6611.2017.03.015
YKL-40与颈动脉粥样硬化斑块稳定性的相关性
Association of YKL-40 levels with carotid atherosclerotic plaque stability
摘要
Abstract
Objective To evaluate the association of YKL-40 level with carotid atherosclerotic plaque stability.Methods In this cross-sectional study,participants were recruited from a community.Information including demographics,behavior and life style,disease history,medicine condition was collected by trained interviewers.The carotid plaques were examined by color ultrasonography.The participants were divided into stable plaque group and unstable plaque group according to the imaging features of color ultrasonography of the dominant plaque.Serum YKL-40 was examined by enzyme-linked immunosorbent assay.According to serum YKL-40 quartiles,subjects were stratified into four groups:low level group (＜ 17.96 ng/ml),low-intermediate level group (17.96-33.40 ng/ml),middlehigh level group (33.40-61.59 ng,/ml),high level group (≥ 61.59 ng/ml).Logistic regression model was used to analyze the association of YKL-40 levels with carotid plaque stability.Results A total of 296 pariticipants with carotid plaques were included in this study,including 116 males (60.8％) with an median age of 69 years,and median YKL-40 concentration of 33.40 ng/ml (quartile:17.96-61.59 ng/ml).Univariate Logistic regression analysis showed that the risk for the instability of carotid atherosclerotic plaque was 3.257 times in high level group compared with low-intermediate level group(P ＜0.05),and 1.836 times in both low level group and low-intermediate level group(P ＞ 0.05).Multivariate Logistic regression analysis showed that after adjusting for age,gender,past history of coronary heart disease,hypertension,diabetes,total cholesterol,triglycerides,low density lipoprotein cholesterol,high density lipoprotein cholesterol,homocysteine and hypersensitive C-reactive protein,the odds ratio was 1.638 (95％ CI 0.580-4.627,P=0.351 3) in low level group compared to low-intermediate level group,2.144 (95 ％ CI 0.786-5.851,P =0.136 3) in middle-high level group,and 2.653 (95 ％ CI 1.002-7.023,P =0.049 6) in high level group.Conclusion YKL-40 level may be associated with carotid atherosclerotic plaque.关键词
YKL-40/颈动脉粥样硬化/斑块稳定性Key words
YKL-40/carotid atherosclerosis/plaque stability分类
医药卫生引用本文复制引用
李柏宏,田蕊,王宇,林金嬉,王伊龙,王拥军,刘改芬,赵锡海,张润华,王蓬莲,薛军,黄曼维,监志东,潘岳松,姜勇..YKL-40与颈动脉粥样硬化斑块稳定性的相关性[J].山西医科大学学报,2017,48(3):266-271,6.基金项目
北京市科技计划重大项目(D131100002313002) （D131100002313002）
首都卫生发展科研专项项目(首发2016-1-2041) （首发2016-1-2041）
“十二五”国家科技支撑计划项目(2011BAI08B01) （2011BAI08B01）
国家自然基金面上项目(81271536) （81271536）
国家自然科学基金资助项目(81200914) （81200914）
“十三五”重点研发计划项目(2016YFC0901001) （2016YFC0901001）
