中国组织工程研究2017，Vol.21Issue(8)：1241-1245,5.DOI:10.3969/j.issn.2095-4344.2017.08.016
不同艾灸距离对Ⅱ型胶原诱导型关节炎疗效的影响
Therapeutic efficacy of moxibustion at different distances on type Ⅱ collagen-induced arthritis
摘要
Abstract
BACKGROUND: Moxibustion can improve the symptoms of rheumatoid arthritis and reduce inflammation, but there are no uniform operation standards. The moxibustion distance becomes one of factor influencing the therapeutic efficacy.OBJECTIVE: To compare the effects of different moxibustion distances on rheumatoid arthritis, and to explore the optimal distance.METHODS: The 8 of 40 male Sprague-Dawley rats were randomly selected as controls. The other 32 were used to make animal modes of collagen type Ⅱ-induced ankle arthritis, and then given moxibustion at Shenshu (BL23) and Zusanli (ST36) at an interval of 1, 2 and 3 cm, respectively, once daily, 10 minutes at each point, 6 days per course for three courses, with a course interval of 1 day. Model rats with no treatment acted as model group.RESULTS AND CONCLUSION: Compared with the control group, the toe volume, arthritis index and serum levels ofinterleukin-1β and tumor necrosis factor-α except the body mass were significantly increased in the model group (P < 0.01).After moxibustion treatment, these indexes were significantly decreased in the three treatment groups (P < 0.01), especially in the 1 and 2 cm groups (P < 0.01). Narrowed articular cavity, intra-articular inflammation and pannus formation were observed in the model group, while only moderate inflammatory cell infiltration and few pannus formation were found in the 1,2, 3 cm groups. These results indicate that moxibustion improves joint functions and regulates immune reaction by downregulating the levels of interleukin-1β and tumor necrosis factor-α, as well as reducing synovial hyperplasia. In addition,the optimal distance for moxibustion is 1 or 2 cm, which is a momentous proposition to improve therapeutic efficacy.关键词
组织工程/骨组织工程/艾灸/距离/胶原诱导型关节炎/类风湿关节炎/细胞因子/白细胞介素1β/肿瘤坏死因子α/关节炎指数/大鼠分类
医药卫生引用本文复制引用
王洋,吴心雨,孙志岭,张永怡,薛莲,秦雪..不同艾灸距离对Ⅱ型胶原诱导型关节炎疗效的影响[J].中国组织工程研究,2017,21(8):1241-1245,5.基金项目
江苏省"青蓝工程"资助项目(2014) （2014）
江苏省普通高校学术学位研究生科研创新计划项目(KYLX16_1164) （KYLX16_1164）
江苏省高等学校大学生创新创业训练计划重点项目(201610315015Z) （201610315015Z）
江苏省优势学科二期项目南京中医药大学护理学一级学科指令性课题(YSHL2016-014) Funding: the "Blue Engineering" of Jiangsu Province in 2014 （YSHL2016-014）
the Academic Postgraduate Research Innovation Program of Coleges of Jiangsu Province, No. KYLX16-1164 （）
the Key Project of the Student Innovative Entrepreneurship Training Program in Universities of Jiangsu Province, No. 201610315015Z （）
the Jiangsu Provincial Dominant Subject Second Stage Project of the Nursing Class Ⅰ Instructive Subject of Nanjing University of Chinese Medicine, No. YSHL2016-014 （）
