中国组织工程研究2017，Vol.21Issue(8)：1306-1312,7.DOI:10.3969/j.issn.2095-4344.2017.08.027
组织工程学在泌尿外科应用中的研究与进展
Research advancement of tissue engineering in urology
摘要
Abstract
BACKGROUND: Tissue engineering provides a new way for the repair of urinary tissue and organ defects.Urinary tissue engineering has shown a bright prospect.OBJECTIVE: To review the latest research on urinary tissue engineering at national and international level.METHODS: With the keywords of "tissue engineering, urology, scaffold, vascularization" in Chinese and in English,respectively, a computer-based search for articles published from January 2000 to January 2016 was performed in CNKI and PubMed databases. The articles addressing urology tissue engineering, scaffolds and vascularization were collected,summarized and analyzed.RESULTS AND CONCLUSION: The selection and cultivation of seed cells, scaffold material performance, tissue construction in vitro, and degree of vascularization all make an important influence on the repair of urinary injuries. As different seed cells hold different biological characteristics, we should make full consideration prior to choosing an appropriate seed cell, so as to pave a good foundation for urinary tissue engineering. Scaffolds with good three-dimensional structure can promote the cell growth and proliferation, tissue in-growth and vascularization.Tissue-engineered materials are superior to traditional repair materials, but still on initial stage, and further large scale trials will be necessary. Moreover, some problems needed to be solved, such as the regenerated tissue with incomplete function different from natural tissues, and regeneration failure caused by biological stent rejection.关键词
组织构建/组织工程/泌尿外科/种子细胞/支架材料/国家自然科学基金分类
医药卫生引用本文复制引用
孙恒,赵战魁,孟琳,于红莲,孔庆胜..组织工程学在泌尿外科应用中的研究与进展[J].中国组织工程研究,2017,21(8):1306-1312,7.基金项目
国家自然科学基金(81500517 ,81402119) （81500517 ,81402119）
山东省自然科学基金(ZR2014HL071 ,ZR2013CM031 , ZR2014HP055) （ZR2014HL071 ,ZR2013CM031 , ZR2014HP055）
济宁医学院附属医院博士基金(2016-BS-010)Funding:the National Natural Science Foundation of China, No. 81500517 and 81402119 （2016-BS-010）
the Natural Science Foundation of Shandong Province, No. ZR2014HL071, ZR2013CM031 and ZR2014HP055 （）
the Doctoral Fund of the Affiliated Hospital of Jining Medical University, No. 2016-BS-010 （）
