眼科新进展2017，Vol.37Issue(3)：239-243,5.DOI:10.13389/j.cnki.rao.2017.0060
应用静息态功能磁共振成像分数低频振幅技术研究中高度近视患者大脑活动的异常改变
A resting-state fMRI study on brain functional activity changes m moderate and high myopia patients using fractional amplitude of low frequency fluctuation
摘要
Abstract
Objective To investigate the changes of brain function in moderate and high myopia patients using fractional amplitude of low frequency fluctuation (fALFF),and discuss the correlation between brain function changes and clinical data of patients with myopia.Methods Totally 21 moderate and high myopia patients (myopia group),and 21 healthy volunteers (normal control group) who were matched with myopia patients in age and gender,were selected to take rs-fMRI examination.The difference of fALFF of brain functional activity in patients with myopia and normal controls was compared,and the correlation between the changes of fALFF and clinical data of patients with myopia was analyzed,Results Compared with normal control group,the fALFF values of myopia group in the region of the left inferior frontal gyrus,putamen and right inferior frontal gyrus,putamen and insula were significantly lower (all P ＜ 0.05,AlphaSim corrected).However,in bilateral cingulate gyrus,bilateral anterior cingulate gyrus,left postcentral gyrus,left superior parietal lobule and region,fALFF values were increased (all P ＜ 0.05,AlphaSim corrected).Conclusion Patients with myopia are accompanied by abnormal neuronal activity in many brain areas,which may reflect the dysfunction of language understanding and attention control in myopic patients.关键词
近视/静息态功能磁共振成像/分数低频振幅Key words
myopia/resting state functional magnetic resonance imaging/fractional amplitude of low frequency fluctuation分类
医药卫生引用本文复制引用
胡裕翔,周荃,李宇平,许晓璇,吴一凡,刘克政,占敏艳,吴晓蓉..应用静息态功能磁共振成像分数低频振幅技术研究中高度近视患者大脑活动的异常改变[J].眼科新进展,2017,37(3):239-243,5.基金项目
国家自然科学基金资助(编号:81360151) （编号:81360151）
江西省科技支撑计划项目(编号:20141BBG70027) （编号:20141BBG70027）
江西省教育厅科技计划项目(编号:GJJ13147) （编号:GJJ13147）
江西省卫计委科技计划项目(编号:20141031) （编号:20141031）
2012年江西省远航工程 （）
2016年南昌大学研究生创新专项资金(编号:cx2016307)National Natural Science Foundation of China (No:81360151) （编号:cx2016307）
Technology and Science Foundation of Jiangxi Province (No:20141BBG70027) （No:20141BBG70027）
Jiangxi Province Education Department Scientific Research Foundation (No:GJJ13147) （No:GJJ13147）
Health Development Planning Commission Science Foundation of Jiangxi Province (No:20141031) （No:20141031）
2012 Province Voyage Project （）
2016 Nanchang University Graduate Innovation Special Funds (No:cx2016307) （No:cx2016307）
