中国临床药理学杂志2017，Vol.33Issue(3)：206-208,3.DOI:10.13699/j.cnki.1001-6821.2017.03.004
替罗非班注射剂对氯吡格雷抵抗性急性冠状动脉综合征患者介入治疗的临床研究
Clinical trial of tirofiban injection in the acute coronary syndrome patients with clopidogrel resistance during intervention
摘要
Abstract
Objective To observe the clinical efficacy and safety of tirofiban injection in the acute coronary syndrome patients with clopidogrel resistance during intervention.Methods A total of 54 patients with acute coronary syndrome and clopidogrel resistance were randomly divided into control group (n =27 cases) and treatment group (n =27 cases).Control group was given clopidogrel 150 mg qd oral,then changed to 75 mg per times after 10 d.Treatment group was treated with tirofiban 10 μg · kg-1,intravenous bolus,then changed to tirofiban 0.1 μg kg-1 min-1,intravenous infusion for 48 h,and clopidogrel 75 mg qd oral.Two groups were treated for 15 d.The levels of platelet α granule glycoprotein (CD62p) and platelet membrane glycoprotein Ⅱ a-Ⅲ b complex fibrinogen receptor (PAC-1),adverse drug reactions were compared between two groups.Results After treatment,the levels of CD62p treatment and control groups were (3.26 ± 0.43) ％,(7.98 ± 1.14％);PAC-1 in treatment and control groups were (3.42 ± 0.37) ％,(7.88 ± 1.09) ％,with significant difference (P ＜ 0.05).The adverse drug reactions in the two groups were based on death,cardiovascular adverse events and bleeding.The incidences of treatment and control groups were 11.11％ and 40.74％ with significant difference (P ＜ 0.05).Conclusion Tirofiban injection can significantly reduce the levels of CD62p and PAC-1 in acute coronary syndrome patients with clopidogrel resistance during intervention,and reduce the incidence of cardiovascular adverse events without increasing the incidence of bleeding.关键词
替罗非班/氯吡格雷抵抗/急性冠状动脉综合征/介入治疗/安全性Key words
tirofiban/clopidogrel resistance/acute coronary syndrome/interventional therapy/safety分类
医药卫生引用本文复制引用
沈彦祥,孙智睿,苍春阳..替罗非班注射剂对氯吡格雷抵抗性急性冠状动脉综合征患者介入治疗的临床研究[J].中国临床药理学杂志,2017,33(3):206-208,3.基金项目
齐齐哈尔市科学技术计划基金资助项目(2015L019) （2015L019）
