中国临床药理学杂志2017，Vol.33Issue(3)：219-221,3.DOI:10.13699/j.cnki.1001-6821.2017.03.008
甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究
Clinical trial of insulin glargine combined with acarbose on type 2 diabetes with secondary failure
摘要
Abstract
Objective To investigate the clinical efficacy of insulin glargine combined with acarbose on type 2 diabetes with secondary failure.Methods Eighty cases of type 2 diabetes with secondary failure were selected and treated with insulin glargine 10 U every time,qd;acarbose 50 mg,tid.The dose was adjusted according to the changes of the blood glucose.All patients were treated for 3 months.Clinical efficacy,blood glucose and incidence of adverse drug reactions were observed.Results After treatment,the clinical effective rate was 90.00％ (72/80 cases).The levels of fasting blood glucose,postprandial blood glucose,and glycosylated hemoglobin (HbA1 c) were (6.23 ± 1.26) mmol · L-1,(8.35 ±2.18)mmol · L-1,(6.64 ± 1.23)％ after treatment,significantly lower than those before treatment,which were (9.34 ± 2.04) mmol · L-1,(12.15 ±3.61) mmol · L-1,(8.82 ±2.53) ％.The incidence of adverse reactions such as dizziness,palpitation,sweating,blurred vision was 8.75％(7/80 cases),which disappeared after symptomatic treatment.Conclusion Insulin glargine combine with acarbose was effective in the treatmem of diabetic patients with secondary failure,which can effectively controll blood glucose level,with low incidence of adverse drug reactions.关键词
继发性失效/糖尿病/甘精胰岛素/阿卡波糖Key words
secondary failure/diabetes/insulin glargine/acarbose分类
医药卫生引用本文复制引用
杨华,许学忠,祁平,吴海清,张艳..甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究[J].中国临床药理学杂志,2017,33(3):219-221,3.基金项目
海南省卫计委基层适宜技术推广基金资助项目[琼卫科教2015(74)号] （74）
