中国临床药理学杂志2017，Vol.33Issue(3)：232-234,3.DOI:10.13699/j.cnki.1001-6821.2017.03.012
2011年至2015年耐亚胺培南大肠埃希菌临床分离株的耐药性分析
Antimicrobial resistance profiles of the imipenem-resistant Escherichia coli clinical isolates from 2011 to 2015
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance profiles of the imipenem-resistant Escherichia coli clinical isolates.Methods A total of 10428 Escherichia coli isolates were isolated from various specimens of patients at the first affiliated hospital of Wenzhou medical university from January 2011 to November 2015.The identification and antimicrobial susceptibility testing for Escherichia coli isolates were determined by VITEK Full Automated Microbiology Analyzer.Results Among 10428 Escherichia coli clinical isolates,including 62.69％ ESBLs-producing isolates,84(0.81％) were resistant to imipenem.The rates of imipenem resistance among Escherichia coli isolates from 2011 to 2015 were 0.14％ (2/1397 strains),0.47％ (9/1898strains),0.55％ (12/2170 strains),0.88％ (22/2489 strains) and 1.58％ (39/2474 strains).Among 84 imipenem-resistant isolates,50.00％ (42/84 strains) were ESBLs-producing isolates;the non-susceptibility rates of all imipenem-resistant isolates to cefazolin,ampicillin,ampicillin/sulbactam,ertapenem and ceftriaxone were more than 90.00％.However,the susceptibility rates of these isolates to nitrofurantion and amikacin were more than 50.00％ (50.00％ and 62.50％).The susceptibility rates of imipenem-resistant isolates to other types of antibiotics were less than 30.00％.Conclusion Imipenem has fine antimicrobial activity in vitro against Escherichia coli isolates.However,the prevalence of imipenem resistance among Escherichia coli clinical isolates is increasing year by year.关键词
大肠埃希菌/亚胺培南/耐药率Key words
Escherichia coli/imipenem/resistance分类
医药卫生引用本文复制引用
陈韩,陈思思,余方友..2011年至2015年耐亚胺培南大肠埃希菌临床分离株的耐药性分析[J].中国临床药理学杂志,2017,33(3):232-234,3.基金项目
浙江省科技创新团队基金资助项目(2011R50018-11) （2011R50018-11）
