中国临床药理学杂志2017，Vol.33Issue(3)：262-264,3.DOI:10.13699/j.cnki.1001-6821.2017.03.020
利巴韦林注射液联合清开灵注射液治疗小儿病毒性肺炎的临床研究
Clinical trial of ribavirin injection combined with qingkailing injection in the treatment of children with virus pneumonia
摘要
Abstract
Objective To observe the clinical efficacy and safety of ribavirin injection combined with qingkailing injection in the treatment of children virus pneumonia.Methods A total of 105 children with viral pneumonia were randomly divided into control group (n =52 cases) and treatment group (n =53 cases).Control group was given intravenous infusion of ribavirin injection 10 mg · kg-1 · d-1 qd.Treatment group was treated with intravenous infusion of qingkailing injection,which was given 6 mL qd for 1-2 years children and 10 mL qd for 3-6 years children,on the basis of control group.Two groups were treated for 7 d.The clinical efficacy,levels of inflammatory cytokine,lung function indexes,disappearance time of symptoms and signs,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.45％ (49/53cases) and 73.08％ (38/52 cases)with significance difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:interleukin-6 were (23.13 ± 5.12),(42.91 ± 6.81) ng · L-1;interleukin-8 were (9.10 ± 2.13),(15.03 ± 3.51) ng · L-1;tumor necrosis factor-α were (27.12 ± 4.67),(38.97-9.09)ng · L-1;per kilogram of tidal volume were (7.93--1.29),(6.73 ± 1.20)mL · kg-1;peak expiratory time / expiratory time were (45.13 ± 6.78) ％,(32.16 ± 5.71) ％;respiratory rates were (23.51 ± 4.59),(27.98 ±4.12) beat · min-1;fever clearance time were (2.19 ±0.61),(4.21 ± 1.30) d;disappearance time of cough were (4.31 ± 1.27),(5.98 ± 1.43) d;disappearance time of pulmonary rales were (3.41 ± 1.04),(5.59 ± 1.43)d,the differences were statistically significant (P ＜ 0.05).There were no adverse drug reactions occurred during the treatment.Conclusion Qingkailing injection combined with ribavirin injection has a definitive clinical efficacy and safety in the treatment of children virus pneumonia,which can improve the lung function obviously and reduce the inflammatory reactions.关键词
利巴韦林/清开灵注射液/小儿病毒性肺炎/肺功能/炎症反应Key words
ribavirin injection/qingkailing injection/children viral pneumonia/pulmonary function/inflammatory reaction分类
医药卫生引用本文复制引用
李吉红,邓焰,兰德联,汪泽,汪永强..利巴韦林注射液联合清开灵注射液治疗小儿病毒性肺炎的临床研究[J].中国临床药理学杂志,2017,33(3):262-264,3.基金项目
国家医学教育发展中心医学研究基金资助项目(2010-37-01-029) （2010-37-01-029）
