中国临床药理学杂志2017，Vol.33Issue(3)：284-288,5.DOI:10.13699/j.cnki.1001-6821.2017.03.026
错配修复系统在肿瘤形成中的作用研究进展
Progress in mismatch repair system in tumor formation
靳振岭 1赵丹 1丁铭1
作者信息
- 1. 陕西省第四人民医院重症医学科,西安710043
- 折叠
摘要
Abstract
Defects in DNA repair play an important role in tumor formation.Microsatellites located in the genome are the most prone to mismatches in the DNA replication process.Mismatch repair gene (MMR) is required to repair the mismatch repair mechanism.If the MMR mutation results in loss of function,it will lead to tumorigenesis.In this paper,the previous DNA mismatch repair system and its role in the tumor in each system will be summarized,hoping to provide the basis for the future research of tumor formation in the molecular level and its treatment.关键词
DNA错配修复/微卫星/错配修复基因/微卫星不稳定性/肿瘤Key words
DNA mismatch repair/microsatellite/mismatch repair gene/microsatellite instability/tumor分类
医药卫生引用本文复制引用
靳振岭,赵丹,丁铭..错配修复系统在肿瘤形成中的作用研究进展[J].中国临床药理学杂志,2017,33(3):284-288,5.
