中国临床药理学杂志2017，Vol.33Issue(4)：294-296,3.DOI:10.13699/j.cnki.1001-6821.2017.04.002
神经节苷脂注射液治疗重症颅脑损伤患者的临床研究
Clinical trial of ganglioside injection in the treatment of patients with severe craniocerebral injury
摘要
Abstract
Objective To investigate the correlation between ganglioside (Gg) injection and serum neuron-specific enolase (NSE) and S100B protein concentration in patients with severe craniocerebral injury.Methods Sixty-eight patients with acute craniocerebral injury were randomly divided into control group (n =34) and treatment group (n =34).Patients in control group were intravenously infused mannitol injection 200 mL,twice a day and orally given norepinephrine 1.2 g,3 times a day.Patients in treatment group were given intravenous infusion of monosialoglycoside ganglion glucoside 100 mg,once a day.All patients were treated for 2 months.Serum NES and S100B protein levels were measured by enzyme-linked immunosorbent assay in two groups in 24,48,72,and 120 h after hospitalization.And the adverse drug reactions in two groups were observed.Results After 120 h treatment,the serum NSE levels in treatment group and control group were (13.21 ± 2.78),(18.52 ± 3.45) ng· mL-1.The S100 in treatment group and control group were (2.08 ±0.85),(3.76 ±2.14) ng · mL-1(P＜0.05).The effective rate was 82.35％ (28/34 cases) in treatment group,had significant difference with that in control group,which was 58.82％ (20/34 cases,P ＜ 0.05).The MMSE scores in treatment group after 2,4 weeks were 23.44 ± 3.15,27.41 ± 3.48,had significant difference with those in control group,which were 20.35 ± 2.35,22.24 ± 2.97 (P ＜ 0.01).There were no adverse drug reactions in two groups during the treatment.Conclusion Gg injection can effectively reduce the levels of serum NSE and S100B protein in patients with severe traumatic brain injury.关键词
急性颅脑损伤/神经节苷脂注射液/神经元特异性烯醇化酶蛋白/酶联免疫吸附法Key words
acute brain injury/gangliosides injection/neuron-specific enolase protein/enzyme-linked immunosorbent assay分类
医药卫生引用本文复制引用
费毅,王鹏程,陈宝智,陈建南,彭其斌,曾敏..神经节苷脂注射液治疗重症颅脑损伤患者的临床研究[J].中国临床药理学杂志,2017,33(4):294-296,3.基金项目
国家自然科学基金资助项目(81260043) （81260043）
海南省医学科研重点基金资助项目(2012ZD-06) （2012ZD-06）
