中国临床药理学杂志2017，Vol.33Issue(4)：297-300,4.DOI:10.13699/j.cnki.1001-6821.2017.04.003
2型糖尿病患者血清抵抗素和瘦素及脂联素水平与颈动脉斑块的相关性研究
Correlation among the levels of serum resistin, adiponectin and leptin and carotid plaque in patients with type-2 diabetes mellitus
摘要
Abstract
Objective To investigate the correlation among the levels of serum resistin,adiponectin and leptin,the carotid intima-media thickness (IMT) and the stability of plaque in patients with type-2 diabetes mellitus (T2DM).Methods A total of 60 T2DM patients were in T2DM group,50 patients with impaired glucose tolerance (IGT) were in IGT group,and 50 healthy volunteers were in the control group.Fasting serum resistin,adiponectin,and leptin were detected by enzyme-linked immunosorbent assay (ELISA) and the IMT and plaque formation were measured.Results Serum Resistin (RET) in IGT group and T2DM group were (3.26 ± 1.85),(4.61 ±2.08)ng · mL-1,leptin (LEP) were (1.83 ±0.09),(3.10±0.15)ng · mL-1,adiponectin (APN) were (3.57 ±0.11),(1.61 ±0.12)μg· mL-1,IMT were (1.15 ± 0.04),(1.59 ± 0.12) mm,and the detection rates of atheromatous plaque were 10.00％ and 51.67％,and differences of the above parameters were significant (P ＜ 0.05).RET of T2DM patients in no plaques group,stable plaques group and unstable plaques group were (3.01 ± 1.25),(4.17 ± 1.08) and (5.35 ±1.16)ng · mL-1 respectively;LEP were (1.33 ±0.15),(2.21 ±0.12)and(3.15 ±0.17)ng · mL-1 respectively;APN were (2.81 ± 0.10),(1.95 ± 0.09) and (1.14 ± 0.12) μg · mL-1 respectively,and all the parameters were with statistical significance among the three groups (P ＜ 0.05).RET was found positively correlated with LEP (P ＜0.01),and APN was negatively correlated with RET and LEP respectively (P ＜ 0.01).Conclusion The increased levels of serum RET,LEP,and APN in T2DM patients are closely related with the bodiness of carotid artery IMT,the formation of the plaque and the stability.关键词
2型糖尿病/血清抵抗素/瘦素/脂联素/颈动脉斑块/相关性Key words
type 2 diabetes mellitus/serum resistin/adiponectin/leptin/carotid artery plaque/correlation分类
医药卫生引用本文复制引用
王立坤,武雪亮,杨占清,张军,史丽,杨瑞敏,王义成..2型糖尿病患者血清抵抗素和瘦素及脂联素水平与颈动脉斑块的相关性研究[J].中国临床药理学杂志,2017,33(4):297-300,4.基金项目
河北省卫计委医学科学研究重点课题计划基金资助项目(20160367) （20160367）
