中国临床药理学杂志2017，Vol.33Issue(4)：304-307,4.DOI:10.13699/j.cnki.1001-6821.2017.04.005
左甲状腺素钠片对妊娠伴甲状腺功能减退患者的临床研究
Clinical trial of levothyroxine sodium on thyroid function in pregnant women with hypothyroidism
摘要
Abstract
Objective To evaluate the clinical effect of levothyroxine sodium on serum lipid levels and thyroid function in pregnant women with hypothyroidism.Methods Fifty-two pregnancy patients with hypothyroidism were randomly divided into control group and treatment group,26 cases in each group.The control group was given conventional therapy,including the amount of added salt,plenty of high quality protein,appropriate low-fat diet.Treatment group was treated with levothyroxine sodium 50 μg,qd on the basis of control group.Levels of serum total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),serum thyroid stimulating hormone (TSH),free thyroid hormone (FT4),free three iodine thyroid acid (FT3) and incidence of pregnancy complications were compared between the two groups.Results After treatment,levels of TC in treatment and control groups were (4.22 ± 0.59),(5.32 _ 0.69) mmol · L-1.Levels of TG in treatment and control groups were respectively (2.11 ±0.25),(2.84 ±0.39) mmol· L-1.Levels of LDL-C in treatment and control groups were (2.18 ±0.31),(3.11 ±0.37) mmol · L-1.Levels of HDL-C in treatment and control groups were (1.82 ±0.26),(1.56 ±0.22) mmol · L-1.Levels of TSH in treatment and control group were (2.03 ± 0.25),(2.45 ± 0.34) pmol · L-1.Levels of FT4 in treatment and control groups were respectively (18.43 ±2.61),(10.84 ± 1.57) pmol · L-1.Levels of FT3 in treatment and control groups were (5.73 ± 0.81),(3.35 ±0.47) pmol · L-1.There were significant difference in TC,TG,LDL-C,HDL-C,TSH,FT4,FT3 between the two groups after treatment (P ＜ 0.05).There were 2 cases of gestational hypertension,1 case of gestational diabetes mellitus,1 case of intrahepatic cholestasis,2 cases of fetal growth restriction,the incidence of pregnancy complications was 23.08％ (6/26).There were 1 case of hypertension,1 case of gestational diabetes mellitus,1 case of intrahepatic cholestasis,and the incidence of pregnancy complications was 11.54％ (3/26),the difference had no statistical significance (P ＞ 0.05).Conclusion Levothyroxine sodium can significantly reduce the levels of blood lipids in pregnancy patients with hypothyroidism,improve thyroid function,and reduce the incidence of pregnancy complications.关键词
左甲状腺素钠片/妊娠伴甲状腺功能减退/血脂/甲状腺功能Key words
levothyroxine sodium/pregnancy with hypothyroidism/blood lipid/thyroid function分类
医药卫生引用本文复制引用
边德志,刘艳梅,胥柯,钱晓娟,于建成..左甲状腺素钠片对妊娠伴甲状腺功能减退患者的临床研究[J].中国临床药理学杂志,2017,33(4):304-307,4.基金项目
盐城市医学科技发展计划基金资助项目(YK2014006) （YK2014006）
