中国临床药理学杂志2017，Vol.33Issue(4)：335-337,342,4.DOI:10.13699/j.cnki.1001-6821.2017.04.013
参麦注射液对母婴分离新生鼠脑损伤的保护作用
Protective effect of Shenmai injection on the behavior change in adult rats after neonatal maternal separation
摘要
Abstract
Objective To study the protective effect of Shenmai injection (SI)on the behavior change in adult rats after neonatal maternal separation.Methods Neonate-mother separation (NMS) animal model was replicated.The rats in maternal separation group were separated for 3 h per day on postnatal days 2 to 21.Neonatal rats were divided randomly into three groups (n =12):control group,model group (NMS),experimental group (SI).Each group had twelve rats.After two months,the behavior changes of adult rats were tested.The expression of Bcl-2 in hippocampus was detected by immunohistochemical method.Results The total distances in experimental group and model group were (15.17 ± 5.32),(12.32 ± 2.74) m with significant difference (P ＜ 0.05).The average speeds in experimental group and model group were (0.09 ± 0.03),(0.07 ± 0.04) m · s-1 with significant increase (P ＜ 0.05),But not to the same as that of control group.The expression of hippocampus Bcl-2 in model group,control group and experimental group were 110.34 ± 37.32,92.62 ± 52.13,152.17 ± 29.65 with significantly increased in model group compared with control group (P ＜0.05);while decreased in experimental group compared with model group (P ＜0.05).But not to the same as that of control group.Conclusion Shenmai injection possibly can improve the cognitive impairment,which may be related to the upregulation of the expression level of apoptosis gene Bcl-2.关键词
新生期母婴分离/三桶互通脑功能仪/参麦注射液/Bcl-2蛋白Key words
neonatal mother separation/three links exchange apparatus of brain function/Shenmai injection/Bcl-2 protein分类
医药卫生引用本文复制引用
党嘉文,孙鸿燕,董文斌,李清平,冯志强,雷小平..参麦注射液对母婴分离新生鼠脑损伤的保护作用[J].中国临床药理学杂志,2017,33(4):335-337,342,4.基金项目
四川省卫生和计划生育委员会科研课题基金资助项目(150069) （150069）
西南医科大学科研课题基金资助项目(2014QN-073) （2014QN-073）
