中国临床药理学杂志2017，Vol.33Issue(4)：359-362,4.DOI:10.13699/j.cnki.1001-6821.2017.04.019
吲哚布芬片预防和治疗缺血性心脑血管病变有效性和安全性的Meta分析
Efficacy and safety of indobufen for prevention and treatment of ischemic cardiovascular and cerebrovascular diseases: a Meta-analysis
杨霞 1刘维 1陈恳 1董淑杰 2翟所迪1
作者信息
- 1. 北京大学第三医院药剂科,北京100191
- 2. 北京大学药学院药事管理与临床药学系,北京100191
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of indobufen in the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases or thrombosis.Methods PubMed,EmBase,Cochrane Library,Web of Science,Clinical Trials.gov,CNKI,CBM and WANFANG database were systematically searched until May 2016.All randomized controlled trials (RCTs) of indobufen therapy in patients with ischemic cardiovascular and cerebrovascular disease or thromboembolic disease were selected.Meta-analysis was carried out by using RevMan 5.3 software.The incidence of cardiovascular death,all-cause mortality,stroke,myocardial infarction,embolism,gastrointestinal reactions and bleeding after the treatment were compared and the results were presented with risk ratio (RR) with 95％ confidence interval (CI).Results Nineteen RCTs of 5304 cases were included in this study,including 2668 cases received indobufen (treatment group),other 2636 cases received other drugs (control group).The results of Meta-analysis were as follows.The incidence of bleeding in the indobufen group was lower than that in the warfarin group (P ＜ 0.01).The incidence of bleeding,gastrointestinal reactions and total adverse effects in the indobufen group were lower than those in aspirin group (P ＜ 0.05).The incidence of bleeding and gastrointestinal reactions in the indobufen group were lower than those in the other antiplatelet drugs group (P ＜ 0.05).The incidence of embolism in the indobufen group was significantly lower than that in the placebo or blank group (P ＜ 0.01).Conclusion Although the clinical application of indobufen is relatively few,it is an efficacious and safe choice for ischemic cardiac and cerebral vascular diseases and thrombosis treatment.There should be more large-scale original researches to explore its clinical value.关键词
吲哚布芬/阿司匹林/华法林/Meta分析Key words
indobufen/aspirin/warfarin/Meta-analysis分类
医药卫生引用本文复制引用
杨霞,刘维,陈恳,董淑杰,翟所迪..吲哚布芬片预防和治疗缺血性心脑血管病变有效性和安全性的Meta分析[J].中国临床药理学杂志,2017,33(4):359-362,4.
