中国临床药理学杂志2017，Vol.33Issue(4)：369-371,3.DOI:10.13699/j.cnki.1001-6821.2017.04.022
对临床药学专业学生应加强精准用药教育
Reinforcement precision medication in clinical pharmacy education
摘要
Abstract
Precision medicine is one of the most important development in the future.In our study,the main contents of precision medication education were presented,and we aimed to provide a reference for clinical pharmacy educators.There are many factors affecting drug efficacy,and the factors could be divided into two categories of genetic and non-genetic factors.Genetic factors include genetic mutations,epigenetic modification,gene expression,miRNA etc.and non-genetic factors can be subdivided into drug-drug interaction,physiological factor,pathological factor,and other factors.Multiple knowledge was related to Precision medicine,such as pharmacogenetics,genetic testing,bioinformatics pharmacogenetics,therapeutic drug monitoring,pharmacometrics and so on.Take warfarin for example,we explained each factor effecting warfarin anticoagulant therapy.The commonly used databases for precise medication were also summarized.Related basic knowledge is the basis of precision medicine.In clinic,specific drug should be analyzed specifically.In order to constantly update knowledge,we should learn to use the common databases.关键词
临床药学/精准用药/遗传因素/非遗传因素Key words
clinical pharmacy/precision medicine/genetic factor/non-genetic factor分类
医药卫生引用本文复制引用
李新刚,余克富,霍记平,朱乐亭,朱斌,赵志刚..对临床药学专业学生应加强精准用药教育[J].中国临床药理学杂志,2017,33(4):369-371,3.基金项目
国家自然科学基金青年基金资助项目(81503157) （81503157）
首都医科大学基础临床合作基金资助项目(16JL72) （16JL72）
北京市优秀人才培养资助青年骨干基金资助项目(2014000021469G258) （2014000021469G258）
