摘要
Abstract
Objective To evaluate the clinical effects of different dosage of caffeine therapy for premature infants with primary apnea. Methods Forty - eight premature infants with primary apnea admittd in Wuhu No. 1 People′s Hospital from January 2014 to March 2016 were selected and divided into low - dose group (n = 24)and high - dose group (n = 24)according to the random number table method. The subjects were treated with caffeine citrate (Chiesi Farmaceutici,batch Number:13512) if apnea occurs 3 times or more a day. The low - dose group took a dose of 20 mg/ kg for the first time,maintenance dose of 5 mg/kg after 24 hours,and received intravenous injection once a day;while the high - dose group took a dose of 20 mg/ kg for the first time,maintenance dose of 10 mg/ kg after 24 hours,and received intravenous injection once a day. Both groups were discontinued drugs (7 ± 3)days after the disappearance of apnea. The treatment effects (including treatment efficiency,success rate of withdrawing respirator and the mechanical ventilation time,oxygen exposure duration during medication),clinical outcomes (including hospital death,bronchopulmonary dysplasia,hospital stay,neurological dysplasia)and occurrence of adverse reactions (tachycardia,feeding intolerance,constipation,anemia,abdominal distension,electrolyte imbalance)of patients in the two groups were compared. Results There were no significant differences in gender,gestational age,body weight,mode of delivery,initiation time of caffeine,maintenance time of caffeine and basic respiratory support between the two groups (P > 0. 05). The effective rate of treatment and success rate of withdrawing respirator in the high - dose group weresignificantly higher than those in the low - dose group (P < 0. 05),while mechanical ventilation time and oxygen exposure duration were not significantly different between the two groups (P > 0. 05). There was no significant difference in the hospital death,incidence of bronchopulmonary dysplasia,hospital stay,and incidence of neurological dysplasia between the two groups (P > 0. 05). There was no significant difference in the incidence of tachycardia,feeding intolerance,constipation,anemia, abdominal distension,and electrolyte imbalance (P > 0. 05). Conclusion Compared with daily maintenance dose of caffeine citrate of 5 mg/ kg,the daily maintenance dose of 10 mg/ kg can better improve the efficacy of premature children with primary apnea and success rate of withdrawing respirator, and at the same time will not increase the incidence of adverse reactions. Therefore,it is worthy of clinical promotion.关键词
婴儿,早产/呼吸暂停/咖啡因/治疗结果Key words
Infant/premature/Apnea/Caffeine/Treatment outcome分类
医药卫生
