中国全科医学2017，Vol.20Issue(10)：1208-1213,1224,7.DOI:10.3969/j.issn.1007-9572.2017.10.014
冠心病患者血浆同型半胱氨酸水平与冠状动脉病变SYNTAX积分的相关性研究
Correlation between the Level of Plasma Hcy and the SYNTAX Score of Coronary Artery Disease of Patients with Coronary Heart Disease
摘要
Abstract
Objective To investigate the correlation between the level of plasma Hcy and the SYNTAX score of coronary artery disease of patients with coronary heart disease (CHD). Methods A total of 225 patients who were definitively diagnosed with CHD after coronary angiography (CAG)at the Department of Cardiology of General Hospital of Ningxia MedicalUniversity from July to December 2014 were selected as CHD group,and 51 patients with negative CAG were selected as the control group. According to the SYNTAX score,patients in CHD group were further divided into low - risk group (n = 74), moderate - risk group (n = 72),high - risk group (n = 79). General information 〔sex,age,BMI,systolic blood pressure (SBP),diastolic blood pressure (DBP),smoking history,history of drinking,past medical history,past medication situation, etc.〕,laboratory test results 〔fasting plasma glucose (FPG),glycosylated hemoglobin (HbA 1c ),total cholesterol (TC), triglyceride (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),serum uric acid (SUA),serum creatinine (SCr),hypersensitive C - reactive protein (hs-CRP),Hcy,etc. 〕,and color Doppler ultrasound examination results of heart 〔left ventricular end diastolic diameter (LVEDD),left ventricular ejection fraction (LVEF)〕of the patients were collected. Results There was no significant difference in age,SBP and DBP among the four groups (P > 0. 05),while there was significant difference in BMI (P < 0. 05). There was no significant difference in the percentage of men,the rate of drinking and the usage rate of antidiabetic drugs,statins and antiplatelet drugs among the four groups (P > 0. 05),while smoking rate and the incidence of hypertension,diabetes and hyperlipidemia as well as the usage rate of antihypertensive drugs were significantly different (P < 0. 05). There were no significant differences in the levels of FPG,TC, SUA and hs-CRP among the four groups (P > 0. 05),while the comparison between levels of HbA 1c ,TG,LDL-C,HDL-C, SCr,Hcy and LVEDD,LVEF was significantly different (P < 0. 05). The level of Hcy was positively correlated with BMI, smoking,hypertension and levels of HbA 1c ,TC,LDL-C,SUA,SCr,hs-CRP as well as LVEDD (P < 0. 05),negatively correlated with HDL-C level and LVEF (P < 0. 05),and had no obvious correlation with other indicators (P > 0. 05). The SYNTAX score was positively correlated with hypertension and levels of SCr,Hcy as well as LVEDD (P < 0. 05),negatively correlated with levels of TG and HDL-C as well as LVEF (P < 0. 05),and had no obvious correlation with other indicators (P >0. 05). Multivariate Logistic regression analysis showed that smoking,hypertension,levels of LDL-C,HDL-C and Hcy,and LVEF were the independent factors of SYNTAX score (P < 0. 05). Conclusion Plasma Hcy level is positively correlated with SYNTAX scores among patients with CHD,and the detection of plasma Hcy level is helpful in predicting the severity of coronary artery disease in patients with CHD.关键词
冠心病/高半胱氨酸/冠状动脉疾病/SYNTAX积分Key words
Coronary disease/Homocysteine/Coronary artery disease/SYNTAX score分类
医药卫生引用本文复制引用
黄晖,张杰,丛广志,沙勇,贾绍斌,严宁,王义勇,杨生平,金萍,王玉玲,崔莹,何琳,张科静..冠心病患者血浆同型半胱氨酸水平与冠状动脉病变SYNTAX积分的相关性研究[J].中国全科医学,2017,20(10):1208-1213,1224,7.基金项目
2012 年宁夏回族自治区教育厅项目 (NGY2012057) （NGY2012057）
