中国全科医学2017，Vol.20Issue(12)：1506-1510,5.DOI:10.3969/j.issn.1007-9572.2017.12.019
微小RNA-124在急性脊柱创伤所致急性脊髓损伤中的诊断价值
Diagnostic Value of miR-124 in Acute Spinal Cord Injury Caused by Acute Spinal Trauma
摘要
Abstract
Objective To investigate the diagnostic value of microRNA - 124 (miR - 124)in acute spinal cord injury (SCI)caused by acute spinal trauma. Methods The subjects enrolled in this study were 45 patients with acute spinal trauma and 15 patients with acute limb trauma admitted to Emergency Medicine Department of the First Affiliated Hospital of Zhengzhou University from September 2014 to September 2015. In accordance with the SCI level evaluated by American Spinal Injury Association (ASIA)Impairment Scale in International Standards for Neurological Classification of Spinal Cord Injury,the patients with acute spinal trauma were divided into complete SCI group (ASIA grade A,n = 15)and incomplete SCI group (ASIA grade B,C,D,n = 15),normal nerve function group (ASIA grade E,n = 15). The patients with acute limb fracture were set as the control group. Peripheral venous blood was taken from the patients in each group within 24 hours after injury and the levels of plasma miR - 124 and serum tumor necrosis factor - alpha (TNF-α)were measured. Results Significant differences in miR - 124 as well as in TNF-α levels were found between the groups (P < 0. 05). Levels of both miR - 124 and TNF-α were higher in the complete SCI group than in normal nerve function group and control group (P < 0. 05). Incomplete SCI group had higher levels of both miR - 124 and TNF-α than the normal nerve function group and control group (P < 0. 05). The area under the curve (AUC)of receiver operating characteristic (ROC)of miR - 124,TNF-α at 24h after injury for diagnosing acute SCI was 0. 948 〔95% CI (0. 890,1. 000)〕,0. 770 〔95% CI (0. 641,0. 879)〕respectively. Conclusion The specificity of miR - 124 for the diagnosis of acute SCI due to spinal trauma is better than that of TNF-α. Therefore,in the future,miR - 124 can be used as a potential marker for the diagnosis of the disease.关键词
脊柱损伤/脊髓损伤/诊断/肿瘤坏死因子-α/微小RNA-124Key words
Spinal injuries/Spinal cord injuries/Diagnosis/Tumor necrosis factor - alpha/miR - 124分类
医药卫生引用本文复制引用
陈聚伍,谢冕,任佳,孟宇..微小RNA-124在急性脊柱创伤所致急性脊髓损伤中的诊断价值[J].中国全科医学,2017,20(12):1506-1510,5.基金项目
国家临床重点专科建设项目(2012-649) （2012-649）
