中国人兽共患病学报2017，Vol.33Issue(1)：49-52,4.DOI:10.3969/j.issn.1002-2694.2017.01.009
ToxoDB#17型弓形虫卵囊对昆明小鼠致病性的研究
Virulence and pathogenicity of Toxoplasma gondii ToxoDB# 17 strain oocysts in Kunming mice
摘要
Abstract
To investigate the pathogenic characteristic of ToxoDB # 17 Toxoplasma gondii in Kunming mice,the mice were fed with ＜1,1,101,102,103,104,105,106 oocysts,and the clinical symptoms of mice were observed.MAT,HE and IHC were used to research the infection rate of T.gondii,survival rate of mice and the number of cysts in brain.The results showed that the mice fed with ≥104 oocysts appeared transient depression,mice were arched,messy hair after infection.The mice fed with ≥102 oocysts were all infected,T.gondii cysts formation rate was 2.38％ (1/42),the survival rate of infected mice was 85.71％ (36/42),the survival time was greater than 360 days.In conclusion,the pathogenicity of ToxoDB# 17 T.gondii is weak,and cysts formation rate is also low.关键词
ToxoDB# 17型弓形虫/昆明小鼠/包囊/致病性Key words
ToxoDB# 17/Toxoplasma gondii/Kunming mice/tissue cysts/pathogenicity分类
医药卫生引用本文复制引用
王凯,冯永杰,付晓莹,陆瑶瑶,梁宏德,杨玉荣..ToxoDB#17型弓形虫卵囊对昆明小鼠致病性的研究[J].中国人兽共患病学报,2017,33(1):49-52,4.基金项目
Supported by the National Natural Science Foundation of China (No.30800812) and the Natural Science Foundation of Henan Province (No.162300410138)国家自然科学基金(No.30800812),河南省自然科学基金资助(No.162300410138) （No.30800812）
