中国人兽共患病学报2017，Vol.33Issue(1)：61-66,6.DOI:10.3969/j.issn.1002-2694.2017.01.012
疱疹病毒US10基因及其编码蛋白研究进展
Advance in Herpesvirus US10 gene and its encoded protein
摘要
Abstract
US10 gene of Herpesvirus is located in the short unique region of its genome and not essential for virus replication.US10 gene encodes a phosphorylated tegument-capsid associated protein or type Ⅰ transmembrane glycoprotein which selectively targets the cytoplasmic tail of HLA-G,a kind of nonclassical class Ⅰ MHC molecular,to reduce and block the host NK cell cytotoxicity in immune evasion.US10 can also interact with host proteins to play a pathogenic role and regulate the expression of other viral proteins such as glycoprotein E (gE).Through further research,the role of US10 in virulence and its ability to combine with RNA and regulate transcription can be judged in the future.关键词
疱疹病毒/US10基因/US10蛋白/免疫逃逸Key words
Herpesvirus/US10 gene/US10 protein/immune evasion分类
医药卫生引用本文复制引用
张代熙,程安春,汪铭书..疱疹病毒US10基因及其编码蛋白研究进展[J].中国人兽共患病学报,2017,33(1):61-66,6.基金项目
Supported by the National Technological Support Projects of China (No.2015BAD12B05) and the China Agricultural Research System (No.CARS-43-8)国家科技支撑计划(No.2015BAD12B05)和国家现代农业(水禽)产业技术体系专项(CARS-43-8) （No.2015BAD12B05）
