中国人兽共患病学报2017，Vol.33Issue(2)：93-97,5.DOI:10.3969/j.issn.1002-2694.2017.02.001
寨卡病毒与登革热病毒交叉反应抗体引发严重性疾病的关系
Relationship of severe diseases induced by cross-reactivity antibodies elicited by infection of Zika virus and Dengue virus
摘要
Abstract
Severe infectious diseases,i.e.antibody-dependent enhancement (ADE) resulted from successive infection with different serotypes of dengue virus.After its introduction into Brazil in 2015,Zika virus has spread rapidly to more than 60 countries and regions by the end of November 2016.Some south-east Asian countries including China have also reported cases of ZIKV infection.In recent studies,it was observed that sera cross-reactivity antibodies or such monoclonal antibodies have been elicited by two domains,ED1 and ED2,of envelope (E) protein on Zika or/and Degue virus,and ADE was easily induced by such antibodies.Dengue fever epidemic often occurred in Chinese coastal provinces each year.Then,it will be followed by Zika virus disease.Therefore,we must pay attention to and propose replying measurement for it.关键词
登革病毒/寨卡病毒/交叉反应蛋白/严重性疾病Key words
dengue virus/zika virus/cross reaction/exacerbation of disease分类
医药卫生引用本文复制引用
严延生,翁育伟..寨卡病毒与登革热病毒交叉反应抗体引发严重性疾病的关系[J].中国人兽共患病学报,2017,33(2):93-97,5.基金项目
Supported by Chinese national high technology research and development program(No.2011AA02A114) （No.2011AA02A114）
国家高技术研究发展计划(No.2011AA02A114)资助 （No.2011AA02A114）
