中国药房2017，Vol.28Issue(9)：1178-1180,3.DOI:10.6039/j.issn.1001-0408.2017.09.07
达比加群、华法林分别用于心房颤动患者射频消融术后疗效与安全性的比较
Comparison of the Efficacy and Safety of Dabigatran and Warfarin Respectively Used in Atrial Fibrillation Patients after Radiofrequency Ablation
孙飞龙 1赵庆春 1任刘丽 1任天舒 1史国兵 1汤雨虹 1王凡非2
作者信息
- 1. 沈阳军区总医院药学部,沈阳 110016
- 2. 沈阳军区总医院心内科,沈阳 110016
- 折叠
摘要
Abstract
OBJECTIVE:To compare the efficacy and safety of dabigatran and warfarin respectively used in atrial fibrillation patients after radiofrequency ablation(RFCA). METHODS:Data of 141 nonvalvular atrial fibrillation patients,who scheduled for RFCA,were retrospectively analyzed and divided into warfarin group(71 cases)and dabigatran group(70 cases)by different med-ication. Patients in warfarin group should stop warfarin if they took before,then changed to Low molecular weight heparin calcium injection 100 U/kg,subcutaneous injection,taking RFCA when INR was lower than 1.5,stopping low molecular weight heparin 12 h before surgery;Low molecular weight heparin calcium injection 100 U/kg was intravenously injected when surgery;orally tak-ing Warfarin sodium tablet 4.5 mg after 4-6 h,once a day,meanwhile bridged overlapping treated at least 3-5 d with low molecu-lar weight heparin;monitoring once INR every 3 d after surgery,maintaining INR 2.0-3.0,taking warfalin at least 3 months. Pa-tients in dabigatran group stopped taking the anticoagulant drugs when admission,then changed to Dabigatran etexilate capsule 110 mg(age≥70 years old or body mass<60 kg)or 150 mg(age<70 years old or body mass≥60 mg),twice a day;stopping dabig-atran 24 h before surgery,the same medication as warfalin group when surgery;orally taking dabigatran after 6 h,taking at least 3 months. The total mortality rate,incidence of stroke(transient cerebral ischemia,ischemic encephalopathy),peripheral thrombosis rate and incidence of bleeding after 1 and 3 month(s)in 2 groups were observed. RESULTS:There were no significant differences in the total mortality rate,incidence of stroke,peripheral thrombosis rate and incidence of bleeding after 1 and 3 month(s) in 2 groups(P>0.05). CONCLUSIONS:Dabigatran has similar anticoagulant efficacy and safety with warfarin in atrial fibrillation pa-tients after RFCA.关键词
心房颤动/射频消融术/华法林/达比加群/疗效/安全性Key words
Atrial fibrillation/Radiofrequency ablation/Warfarin/Dabigatran/Efficacy/Safety分类
医药卫生引用本文复制引用
孙飞龙,赵庆春,任刘丽,任天舒,史国兵,汤雨虹,王凡非..达比加群、华法林分别用于心房颤动患者射频消融术后疗效与安全性的比较[J].中国药房,2017,28(9):1178-1180,3.
