中国药房2017，Vol.28Issue(9)：1249-1253,5.DOI:10.6039/j.issn.1001-0408.2017.09.27
骨痹止痛液的质量标准提高研究
Study on Improving the Quality Standard of Gubi Zhitong Liquor
摘要
Abstract
OBJECTIVE:To improve the quality standard for Guibi zhitong liquor. METHODS:TLC was used for the qualita-tive identification of Radix angelicae,Notopterygium incisum,Radix aucklandiae and Magnolia officinalis in the preparation;HPLC was used for the contents determination of imperatorin and cinnamaldehyde:the column was Waters Symmetry Shield RP-C18 with mobile phase of methanol-water for imperatorin(60:40,V/V)and methanol-water for cinnamaldehyde(35:65,V/V)at a flow rate of 1.0 mL/min,detection wavelength was 254 nm for imperatorin and 290 nm for cinnamaldehyde,column temperature was 25℃,and the injection volume was 20μL. RESULTS:The TLC spots of R. angelicae,N. incisum,R. aucklandiae and M. of-ficinalis were clear and well separated,negative control without interference. The linear range was 3.0-30.0 μg/mL for imperatorin (r=0.9998)and 3.978-39.78 μg/mL for cinnamaldehyde(r=0.9999);RSDs of precision,stability and reproducibility tests were lower than 2.0%;recoveries were 96.94%-102.64%(RSD=2.37%,n=6)and 96.78%-99.53%(RSD=1.00%,n=6). CONCLU-SIONS:The improved standard more effectively control the quality of the Guibi zhitong liquor.关键词
骨痹止痛液/欧前胡素/桂皮醛/薄层色谱法/高效液相色谱法/质量标准Key words
Guibi zhitong liquor/Imperatorin/Cinnamaldehyde/TLC/HPLC/Quality standard分类
医药卫生引用本文复制引用
李喜香,李兴勇,包强,王雪梅..骨痹止痛液的质量标准提高研究[J].中国药房,2017,28(9):1249-1253,5.基金项目
甘肃省中医药科学技术研究课题(No.GZK-2012-45) （No.GZK-2012-45）
