中国肿瘤生物治疗杂志2017，Vol.24Issue(3)：284-289,6.DOI:10.3872/j.issn.1007-385X.2017.03.012
非小细胞肺癌组织PD-L1的表达及其与临床因素的关系
Expression of PD-L1 in NSCLC tissues and its correlation with clinical factors
摘要
Abstract
Objective:To explore the expression levels of programmed death-ligand 1 (PD-1) in cancer tissues of the patients with non-small cell lung carcinoma (NSCLC) in China and their influencing factors.Methods:Expressions of PD-L1,PD-1 and CD3 + T cell in tumor tissues from the 122 patients with NSCLC who were hospitalized in the Cancer Hospital of Tianjin Medical University during April 2008 to August 2014 were tested by Immuno histochemistry assay.x2 and kruskal-wallis tests were used to analyze distribution difference of PD-L1 expression in clinical factors.Person and Spearman tests were to analyze correlation between expression of PD-L1 and EGFR genotype,number of CD3 + T cell,expression of lymphocyte PD-1,and correlation between primary cancer focus and expression of lymphatic node PD-L1.Results:Median expression percentage of PD-L1 in cancer cells of primary tumor was 1.5％ (0-93.2％) in all of the patients.Distribution of the PD-L1 expression in TNM staging had a very significant difference (P ＜ 0.01),expression of PD-L1 positively correlated with TNM staging (r =0.273,P ＜ 0.01) and did not significantly correlate with gender,age,smoking history,maximum tumor diameter,pathological type and level of CEA (P ＞ 0.05);expression level of PD-L1 did not correlate with number of CD3 + T cell and expression level of lymphocyte PD-1,negative,low and high expression of PD-L1 did not significantly correlate with EGFR gene mutation (P ＞ 0.05).There was non correlation of PD-L1 expression levels of cancer cells between primary tumor and corresponding metastasis lymph nodes in the 48 NSCLC patients with lymph node metastasis (P ＞ 0.05).Conclusion:PD-L1 expression of primary cancer cells in the patients with NSCLC could have differences in distribution of TNM staging,and don't have correlation with number of CD3 + T cell,expression level of lymphocyte PD-1 and EGFR gene mutation.Expression of PD-L1 in cancer cells also could not have correlation between primary tumor locus and corresponding metastasis lymph nodes.关键词
程序性死亡配体1/程序性死亡因子1/表皮生长因子受体/非小细胞肺癌Key words
programmed death-ligand 1 (PD-L1)/programmed death receptor 1/epidermal growth factor receptor(EGFR)/non-small cell lung carcinoma(NSCLC)分类
医药卫生引用本文复制引用
赵宁,任红亮,潘娜,申学杰,吴占波,董一楠,魏枫,张新伟..非小细胞肺癌组织PD-L1的表达及其与临床因素的关系[J].中国肿瘤生物治疗杂志,2017,24(3):284-289,6.基金项目
国家科技支撑计划资助项目(No.2015BA112B12) （No.2015BA112B12）
国家自然科学基金项目(No.81272221,No.81401887).Project supported by the National Science and Technology Support Program (No.2015BA112B12) （No.81272221,No.81401887）
the National Natural Science Foundation of China (No.81272221,No.81401887) （No.81272221,No.81401887）
