中国肿瘤生物治疗杂志2017，Vol.24Issue(3)：290-294,5.DOI:10.3872/j.issn.1007-385X.2017.03.013
长链非编码RNA AFAP1-AS1在胃癌组织中的表达及其临床意义
Expression of AFAP1-AS1 which belongs to lncRNA in gastric carcinoma tissues and its clinical significance
熊钢 1龚江波 2周靖 2刘焰3
作者信息
- 1. 武汉大学基础医学院,湖北武汉430071
- 2. 宜昌市第二人民医院放化疗二科,湖北宜昌443000
- 3. 三峡大学仁和医院妇产科,湖北宜昌443000
- 折叠
摘要
Abstract
Objective:To explore expression of actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1),long non-coding RNA (lncRNA),in the gastric carcinoma tissues and its clinical significance.Methods:Using real-time PCR assay,expressions of AFAP1-AS1 in 274 cases of gastric carcinoma tissues and their corresponding adjacent normal gastric tissues which collected from the patients with gastric carcinoma who were hospitalized in the 24 People Hospital of Yichang City and Renhe Hospital of Sanxia University for operative treatment during January 2010 to December 2014 were detected.And relationship between the expression of AFAP1-AS1 and clinicopathological features of the patients with gastric carcinoma was analyzed.Results:Expression of AFAP1-AS1 in the gastric carcinoma tissue was obviously higher than that in the adjaceut normal gastric tissues.Mean expression amount of AFAP1-AS1 in the early gastric carcinoma tissue was significantly lower than that in the advanced gastric carcinoma tissue (P ＜ 0.01).Among the gastric carcinoma tissues of various pathological types,expression amounts of AFAP1-AS1 were not significantly different (P ＞ 0.05).Expression amounts of AFAP1-AS1 were closely correlated with lymphatic invasion and distant metastasis of the gastric carcinoma.Expression amounts of AFAP1-AS1 in the gastric carcinoma tissue with local invasion and distant metastasis were obviously higher than those in the gastric carcinoma tissues without local invasion and distant metastasis (P ＜ 0.05).Conclusion:AFAP1-AS1 could be an important regulatory factor in the gastric carcinogenesis and development.It could be expected to become a novel marker for judging prognosis of the gastric carcinoma and used for clinical diagnosis and prognosis evaluation of the gastric carcinoma.关键词
长链非编码RNA/肌动蛋白纤维相关蛋白-1反义RNA1/胃癌Key words
long non-coding RNA (lncRNA)/actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1)/gastric cancer分类
医药卫生引用本文复制引用
熊钢,龚江波,周靖,刘焰..长链非编码RNA AFAP1-AS1在胃癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(3):290-294,5.
