中成药2017，Vol.39Issue(3)：455-461,7.DOI:10.3969/j.issn.1001-1528.2017.03.003
黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学
Metabolomics of ethyl acetate extract from Huangqi Injection on leucopenia mice
曲婷丽 1王二兵 2李震宇 3赵正保 2秦雪梅1
作者信息
- 1. 山西医科大学药学院,山西太原030001
- 2. 山西大学中医药现代研究中心,山西太原030006
- 3. 太原科技大学化学与生物工程学院,山西太原030021
- 折叠
摘要
Abstract
AIM To investigate the effects of ethyl acetate extract from Huangqi Injection (HQIEACE) on leucopenia mice.METHODS An experimental mouse model of leucopenia was induced by cyclophosphamide.NMR based metabolomic profiling technique coupled with multivariate statistical method was used for performing metabolomic analysis.RESULTS HQIEACE could elevate the levels of white blood cell,monocytes,neutrophils and lymphocyte in modeled mice.The levels of ten potential endogenous metabolites (lipid,leucine,3-D-hydroxybutyrate,lactate,alanine,pyruvate,creatine,scyllo-inositol,betaine and glucose) were reversed.CONCLUSION The metabolic pathways related to the pharmacological effects of HQIEACE on leucopenia are probably involved in body energy metabolism,amino acid metabolism,oxidative stress and choline metabolism.关键词
黄芪注射液/乙酸乙酯萃取物/代谢组学/NMR/白细胞减少症Key words
Huangqi Injection/ethyl acetate extract/metabolomics/NMR/leucopenia分类
医药卫生引用本文复制引用
曲婷丽,王二兵,李震宇,赵正保,秦雪梅..黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学[J].中成药,2017,39(3):455-461,7.
