中成药2017，Vol.39Issue(3)：462-466,5.DOI:10.3969/j.issn.1001-1528.2017.03.004
甘草次酸抑制胃溃疡大鼠胃黏膜细胞的凋亡
Glycyrrhetinic acid inhibits the apoptosis of gastric mucosa cells in gastric ulcer rats
孙俊波 1赵璐 2史素琴 3寇振媛 4刘爱娟 1付婷婷3
作者信息
- 1. 河南省中医院,河南中医药大学第二附属医院,河南郑州450002
- 2. 河南中医药大学中医学博士后流动站,河南郑州450046
- 3. 河南中医药大学第三附属医院,河南郑州450008
- 4. 河南中医药大学第一附属医院,河南郑州450000
- 折叠
摘要
Abstract
AIM To explore the effects of glycyrrhetinic acid on the gastric ulcer rats infected by Helicobacter pylori (Hp) and its action mechanism.METHODS Gastric ulcer rat models were induced by acetic acid stress and then followed by Hp infection.After treatment with low and high doses of glycyrrhetinic acid,the ulcer index,gastric acid and proteinase activities in gastric ulcer rats were analyzed.The effects of glycyrrhetinic acid on the expressions of BCL2 and Caspase-3,the GSK3β activity in gastric mucosa and gastric epithelial cells,and the cell apoptosis level were then detected.RESULTS Glycyrrhetinic acid reduced the ulcer index,gastric acid and proteinase activities in rats.Besides,the expression of BCL2 was significantly up-regulated by glycyrrhetinic acid in gastric mucosa and gastric epithelial cells,whereas the expression of Caspase-3,level of cell apoptosis,and GSK3β activity were significantly reduced.After the treatment with GSK3 β activator LY294002,the level of BCL2 was down-regulated,Caspase-3 expression was increased,and the level of cell apoptosis was enhanced.CONCLUSION Glycyrrhetinic acid promotes the healing of gastric ulcer infected by Hp via regulating GSK3β activity and inhibiting apoptosis of gastric epithelial cells.关键词
甘草次酸/幽门螺杆菌/胃溃疡/细胞凋亡/GSK3βKey words
glycyrrhetinic acid/Helicobacter pylori/gastric ulcer/cell apoptosis/GSK3β分类
医药卫生引用本文复制引用
孙俊波,赵璐,史素琴,寇振媛,刘爱娟,付婷婷..甘草次酸抑制胃溃疡大鼠胃黏膜细胞的凋亡[J].中成药,2017,39(3):462-466,5.
