中成药2017，Vol.39Issue(3)：475-479,5.DOI:10.3969/j.issn.1001-1528.2017.03.007
生姜泻心汤治疗伊立替康导致的结直肠癌小鼠迟发性腹泻
Shengjiang Xiexin Decoction treats irinotecan-induced delayed diarrhea in colorectal carcinoma mice
摘要
Abstract
AIM To observe the therapeutic effects of Shengjiang Xiexin Decoction (Zingiberis recens Rhizoma,Zingiberis Rhizoma,Coptidis Rhizoma,etc.) on irinotecan (CPT-11)-induced delayed diarrhea in colorectal carcinoma mice and to discuss its possible action mechanism.METHODS The AOM/DSS-induced female colorectal carcinoma mice were randomly divided into normal group,model group and Shengjiang Xiexin Decoction group.The Shengjiang Xiexin Decoction group was intragastrically administered with Shengjiang Xiexin Decoction,the normal group and the model group were intragastrically administered with normal saline.The diarrhea index and rectum pathologic morphology were measured,and the β-glucuronide activity,IL-15 content and UGT1A1 expression were detected.RESULTS The diarrhea index of Shengjiang Xiexin Decoction group was significantly lower than that of the model group,which might be related to the significant inhibition of β-glucuronide activity,and sig-nificant improvement of IL-15 content and UGT1A1 expression.CONCLUSION Shengjiang Xiexin Decoction shows therapeutic effects on irinotecan-induced delayed diarrhea in AOM/DSS-induced colorectal carcinoma mice.关键词
生姜泻心汤/伊立替康(CPT-11)/迟发性腹泻/白介素-15 (IL-15)/尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)Key words
Shengjiang Xiexin Decoction/irinotecan (CPT-11)/delayed diarrhea/IL-15/UGT1A1分类
医药卫生引用本文复制引用
彭罡,关焕玉,王小明,何洋,覃文婷,石钺..生姜泻心汤治疗伊立替康导致的结直肠癌小鼠迟发性腹泻[J].中成药,2017,39(3):475-479,5.基金项目
国家自然科学基金(81274054) （81274054）
北京市自然科学基金(7142109) （7142109）
国家重大新药创制专项(2012ZX09301002-001-028) （2012ZX09301002-001-028）
