中国中西医结合杂志2017，Vol.37Issue(3)：302-305,4.DOI:10.7661/CJIM.2017.03.0302
参麦注射液对冠心病患者血管内皮依赖性舒张功能的影响
Effect of Shenmai Injection on Vascular Endothelial Dependence Diastolic Function in Coronary Heart Disease Patients
摘要
Abstract
Objective To observe the effect of Shenmai Injection (SI) on vascular endothelial dependent diastolic function in coronary heart disease (CHD) patients.Methods Totally 100 recruited CHD patients were assigned to the SI group and the control group by random digit table,50 in each group.All patients received conventional drugs for CHD,50 in each group.Patients in the SI group were intravenously injected with SI,50 mL each time,once per day for 10 days.Changes of brachial artery diameter at hyperemia and sublingual nitroglycerin were measured in all patients before treatment and at day 10 after treatment by intravascular ultrasound.Serum NO level,plasma levels of endothelin (ET),thromboxane B2 (TXB2),6-keto-PGF1α,superoxide dismutase (SOD) were measured using biochemical assay and ELISA.Thirty non-CHD patients confirmed with coronary CT or coronary angiogram were recruited as the non-CHD group.Results Changed value of brachial artery diameter at hyperemia and after sublingual nitroglycerin were more obviously reduced in the CHD group than in the non-CHD group (P ＜0.05,P ＜0.01).Besides,levels of NO,6-keto-PGF1α were lowered,levels of ET and TXB2 were elevated (P ＜0.01).Compared with the control group,congestion of brachial artery was significantly improved,levels of NO and 6-keto-PGF1α increased,SOD concentration was obviously elevated,plasma levels of ET and TXB2 decreased in the SI group (all P ＜0.05).Conclusion SI could directly up-regulate levels of NO and 6-keto-PGF1α,increase SOD activity,decrease levels of ET and TXB2,and improve vascular endothelial dependent vasodilation.关键词
冠心病/血管内皮功能/参麦注射液Key words
coronary heart disease/vascular endothelial function/Shenmai Injection引用本文复制引用
周妍,郭航远,彭放..参麦注射液对冠心病患者血管内皮依赖性舒张功能的影响[J].中国中西医结合杂志,2017,37(3):302-305,4.基金项目
浙江省医学会临床科研基金资助项目(No.2012ZYC-A74) （No.2012ZYC-A74）
