北华大学学报（自然科学版）2017，Vol.18Issue(4)：488-492,5.DOI:10.11713/j.issn.1009-4822.2017.04.015
血浆同型半胱氨酸水平与脑小血管病搏动指数相关性研究
Study of the Relationship between Plasma Total Homocysteine Level and the Pulsatility Index of Cerebral Arteries in Cerebral Small Vessel Diseases
摘要
Abstract
Objective To investigates the relationship between plasma total homocysteine (tHcy) levels and the pulsatity index (PI) of cerebral arteries in cerebral small vessel diseases.Method 180 cases of cerebral small vessel disease patients and 100 control patients were chosen,and plasma tHcy levels of all the patients were detected by chemiluminescent micro particle immunoassay.With a cerebral blood vessel analyzer,the kinematic parameters of bilateral carotid artery were measured,including the maximum carotid blood flow velocity (Vmax),the minimum flow velocity (Vmin),and the mean flow velocity (Vmean);PI values were calculated by using the formula PI=(Vmax-Vmin)/Vmean.Results The plasma tHcy level in patients with cerebral small vessel diseases group is positively correlated with the carotid artery Pulsatility Index (PI),(r=0.326,P=0.002),and negatively with Vmax,Vmin,and Vmean,while there was no such a correlation in the control group.The plasma tHcy level of the white matter lesion patients was significantly higher than that of the Lacunar infarction patients.Conclusion There is a significant correlation between plasma tHcy levels and cerebral artery pulsatility index in patients with cerebral small vessel diseases,which is an independent risk factor in cerebral small vessel diseases patients,and can reflect the degree of injury of the cerebral blood vessels to some extent.关键词
同型半胱氨酸/搏动指数/脑小血管病Key words
homocysteine/cerebral small vessel diseases/pulsatility index分类
医药卫生引用本文复制引用
李贯清,马孝天,张斌,刘宇..血浆同型半胱氨酸水平与脑小血管病搏动指数相关性研究[J].北华大学学报（自然科学版）,2017,18(4):488-492,5.基金项目
安徽省科技计划项目(2015s0379). （2015s0379）
