北京中医药大学学报2017，Vol.40Issue(6)：463-470,8.DOI:10.3969/j.issn.1006-2157.2017.06.004
静宁颗粒对注意力缺陷多动障碍模型大鼠注意定势转移能力的影响
Effects of Jingning Granule on attention set transfer in ADHD rats
摘要
Abstract
Objective To observe the effects of Jingning Granule on attention set shifting (AST) in rats with attention deficit hyperactivity disorder (ADHD).Methods Spontaneously hypertensive rats (SHR) were used as rat model of ADHD.Jingning granule (20.25, 10.125, 5.062 5 g/kg), Methylphenidate HCl Extended-release Tablets (Ritalin 6.75 mg/kg) and pediatric Huanglong granule (0.937 5 g/kg) were used as the intervention respectively and administered continuously for 17 days.The number of errors, burrowing times, and error rate in AST were used as the outcome measures.Results Compared with the normal control group, the number of error, error rate, and burrowing times increased in model group in Simple Discrimination (SD) phase, Compound Discrimination (CD) phase, Intra-Dimensional shift (IDS) phase, Reversal Learning (RL) phase, and Extra-Dimensional shift (EDS) phase;compared with the model group, Jingning granule reduced the frequency of error, error rate, and frequency of burrowing, and improved the attention set shifting defects in ADHD rat model.Conclusion ADHD model rats presented defected attention set shifting, and Jingning granule could effectively improve the attention set transfer ability in ADHD model rats.关键词
静宁颗粒/注意力缺陷多动障碍/注意定势转移能力/大鼠Key words
Jingning granule/ADHD model/attention set transfer ability/rats分类
医药卫生引用本文复制引用
严素玉,张硕峰,张天睿,杨爱玲,张彩峰,马丹..静宁颗粒对注意力缺陷多动障碍模型大鼠注意定势转移能力的影响[J].北京中医药大学学报,2017,40(6):463-470,8.基金项目
国家科技重大专项(No.2014ZX09304306-002)National science and technology major project(No.2014ZX09304306-002) （No.2014ZX09304306-002）
