重庆医学2017，Vol.46Issue(16)：2187-2189,2192,4.DOI:10.3969/j.issn.1671-8348.2017.16.008
HBV宫内感染危险因素的病例对照研究
A case-control study on risk factors for intrauterine HBV infection
摘要
Abstract
Objective To explore the risk factors for hepatitis B virus (HBV) intrauterine infection to provide a scientific ev idence for itsprevention.Methods Three hundred and twelve pregnant women of HBsAg positive screened from April 2013 to May 2015 served as the research subjects and were followed up until 6 months after birth.The infantile mothers of HBsAg and/or HBV DNA positive were selected as the intrauterine infection case group,while other mothers served as the control group.The Logistic regression analysis was adopted to analyze the risk factors for intrauterine HBV infection.The questionnaire survey method was used to collect the basic data and time-resolved immunofluorescence assay was used to detect HBsAg.PCR was adopted to measure level of HBV DNA and automatic biochemistry analyzer was used to measure the hepatic functional parameters including ALT,AST,triglyceride and cholesterol.Results The single factor analysis results indicated that HBeAg,HBV DNA,contamination of amniotic fluid and sexual behavior during pregnancy were related to HBV intrauterine infection(P＜0.05).The multiple variate Logistic regression results showed that positive HBeAg(OR=2.76,95 ％ CI=1.19-7.94),positive HBV DNA(OR=9.62,95 ％ CI=2.58-35.33),and sexual behaviors during pregnancy (OR =1.53,95 ％ CI =1.07-6.40) were the risk factors for intrauterine HBV infection.Conclusion Pregnant women with positive HBeAg,positive HBV DNA and sexual behavior during pregnancy may be the high risk factors for neonatal intrauterine HBV infection.关键词
肝炎病毒,乙型/宫内感染/危险因素/巢式病例对照研究Key words
hepatitis B virus/intrauterine infection/risk factor/a case-control study分类
医药卫生引用本文复制引用
李祥,胡超,王太武,张耀,李亚斐..HBV宫内感染危险因素的病例对照研究[J].重庆医学,2017,46(16):2187-2189,2192,4.基金项目
国家自然科学基金资助项目(81202220). （81202220）
