重庆医学2017，Vol.46Issue(17)：2309-2312,4.DOI:10.3969/j.issn.1671-8348.2017.17.002
OCT检测冠状动脉斑块特征及其与基质金属蛋白酶相关性研究
Study on correlation between OCT for detecting characteristics of coronary artery plaque and matrix metalloproteinase
摘要
Abstract
Objective To apply the optical coherence tomography(OCT) to detect the characteristics of coronary artery plaque and to investigate its correlation with levels of serum matrix metalloproteinase 7(MMP 7),MMP9 and MMP12.Methods The patients undergoing coronary arterial angiography for diagnosing coronary arterial lesions in the cardiology department of our hospital from October 2014 to March 2016 were collected and included into the research subjects.The subjects were divided into the stable plaque group and unstable plaque group based on the results of OCT scanning.The neovascularization characteristics such as the fibrous cap thickness of plaque,angle of lipid pool,macrophage infiltration and plaque cracks were detected by using OCT.ELISA was used to measure serum MMP7,MMP9 and MMP12 levels.Results (1) The fibrous cap thickness in the stable plaque group was more than that in the unstable plaque group(P＜0.01);the lipid pool angle,microphage infiltration,intima erosion and plaque cracks in the unstable plaque group were more than those in the stable plaque group(P＜0.05).(2) The MMP7 and MMP9 levels in the unstable plaque group were higher than those in the stable plaque group and control group(P＜0.05).(3) The fibrous cap thickness had significantly negative correlation with serum MMP9 level(r=-0.336,P=0.034);the MMP7 and MMP9 levels in the microphage infiltration group were higher than those in the non-microphage infiltration group(P＜0.05);the MMP9 level in the intima erosion group was higher than that in the non-intima erosion group(P＜0.01).Conclusion OCT can detect and find unstable plaque and the serum levels of MMP7 and MMP9 are significantly elevated in the patients with unstable plaque,which can be used as an important basis for predicting unstable plaque and guiding the treatment decisions.关键词
冠心病/不稳定斑块/光学相干断层扫描/基质金属蛋白酶类Key words
coronary disease/unstable plaques/optical coherence tomography/matrix metalloproteinases分类
医药卫生引用本文复制引用
孙煌,杨宏波,潘家华,彭云珠,李锐洁,喻雯,孟照辉,郭涛..OCT检测冠状动脉斑块特征及其与基质金属蛋白酶相关性研究[J].重庆医学,2017,46(17):2309-2312,4.基金项目
国家自然科学基金资助项目(81160025) （81160025）
云南省科技厅应用基础研究(2015FB027) （2015FB027）
云南省科技厅科技惠民计划(2014RA011) （2014RA011）
