重庆医学2017，Vol.46Issue(17)：2320-2322,3.DOI:10.3969/j.issn.1671-8348.2017.17.005
中脑腹侧被盖区多巴胺神经元在全身麻醉中的作用研究
Research on effect of midbrain VTA dopaminergic neurons in general anesthesia
摘要
Abstract
Objective To investigate the effect of dopaminergic neurons of midbrain ventral tegmental area(VTA) in general anesthesia.Methods Forty adult healthy male SD rats were randomly divided into lesion group (n=20) and control group (n=20).The lesion group was given the bilateral infusion of specific dopaminergic neuron injury agent 6-OHDA in midbrain lateral VTA,while the control group received the same volume of normal saline at the same areas.The time of loss of righting reflex (LORR)loss and recovery of righting reflex(RORR)at postoperative 2 week were observed in each group.Results Compared with the control group,the LORR time in the lesion group was shortened and the RORR time was significantly prolonged under propofol-induced anesthesia (P＜0.05).However,the LORR time under the isoflurane anesthesia had no statistically significant difference between the two groups(P＞0.05),while the RORR time in the lesion group was increased(P＜0.05).Conclusion Dopaminergic neurons in midbrain VTA might play different roles in the induction and recovery of different general anesthetics.关键词
丙泊酚麻醉/异氟醚麻醉/中脑腹侧被盖区/多巴胺神经元/翻正发射Key words
propofol/isoflurane/midbrain ventral tegmental area/dopaminergic neurons/righting reflex分类
医药卫生引用本文复制引用
刘程曦,谭丹丹,李佳,张益..中脑腹侧被盖区多巴胺神经元在全身麻醉中的作用研究[J].重庆医学,2017,46(17):2320-2322,3.基金项目
国家自然科学基金资助项目(81560237). （81560237）
