重庆医学2017，Vol.46Issue(18)：2449-2452,4.DOI:10.3969/j.issn.1671-8348.2017.18.001
TCF7L2基因rs3814570多态性与新疆维吾尔族人群T2DM的相关性研究
Study on correlation between TCF7L2 gene rs3814570 polymorphisms with T2DM in Uygur Population of Xinjiang
摘要
Abstract
Objective To investigate the correlation between TCF7L2 gene rs3814570 polymorphisms with type 2 diabetes mellitus(T2DM) in Uygur population of Xinjiang area.Methods By adopting the case-control study design,949 cases of T2DM were recruited as the observation group and 963 individuals Undergoing healthy physical examination were selected as the control group.The TCF7L2 gene polymorphism was detected by matrix-assisted laser desorption/ionization-time of flight(MALDI-TOF).Results The statistical differences in frequencies of CC,CT and TT genotypes and the C and T allele frequencies on TCF7L2 rs3814570 were found between the T2DM group and control group(P＜0.05).The risk of suffering from T2DM in the carriers of CT genotype was 0.331 times of that in the carriers of CC genotype(OR =0.331,95 ％ CI:0.166-0.661,P =0.002),the risk of suffering from T2DM in the carriers of TT genotype was 0.539 times of that in the carriers of CC genotype(OR=0.539,95％CI:0.348-0.834,P=0.005),and the risk of suffering from T2DM in the carriers of T allele was 0.501 times of that in the carriers of C allele(OR=0.501,95 ％ CI:0.377-0.664,P＜ 0.01).Among all subjects,the FPG level of the CT + TT genotype group on TCF7L2 gene rs3814570 locus was significantly lower than that of the CC genotype group(P＜0.05).Conclusion The rs3814570 locus in TCF7L2 gene may be associated with T2DM occurrence in Uygur population of Xinjiang area,the T allele and TT genotype might be protective factors of T2DM.关键词
多态性,单核苷酸/转录因子7类似物2基因/糖尿病,2型/维吾尔族Key words
polymorphisms,single nucleotide/the transcription factor 7-like 2 gene/diabetes mellitus,type 2/Uygur Nationality分类
医药卫生引用本文复制引用
王志强,刘莉娜,朱筠,姚华,马琦,苏银霞,王黎,李豫凯,丁丽丽..TCF7L2基因rs3814570多态性与新疆维吾尔族人群T2DM的相关性研究[J].重庆医学,2017,46(18):2449-2452,4.基金项目
国家重点基础研究发展计划(973计划)资助项目(2012CB722403). （973计划）
