分析化学2017，Vol.45Issue(6)：874-882,9.DOI:10.11895/j.issn.0253-3820.160916
顺丁烯二酸β-环糊精酯-N-乙烯基吡咯烷酮水溶性聚合物的合成及其吸附疏水性药物的研究
Synthesis of β-Cyclodextrin-N-vinyl-2-pyrrolidone Water-SolubleCopolymer and Its Adsorption of Hydrophobic Drugs
摘要
Abstract
β-Cyclodextrin-N-vinyl-2-pyrrolidone (CDM-NVP) copolymer was prepared by free radical chain reaction of N-vinyl-2-pyrrolidone (NVP) and β-CD maleate (CDM) with γ-ray as initiator.The synthesis conditions of CDM-NVP polymer were as follows: mass ratio of CDM to NVP was 1∶0.7 (CDM 3.6 g and NVP 2.52 g), irradiation dosage was 4 kGy, and DMF aqueous solution (50%, V/V) was set at 20 mL.Under the synthesis conditions, the yield of CDM-NVP was 84% and the weight-average molecular weight was 20 kD.The natamycin (NM) and carbendazim (MBC) could form stable inclusion complexes with CDM-NVP copolymer, and the solubility and fungicidal activity of the complexes were investigated.The stability constant of NM·CDM-NVP and MBC·CDM-NVP complexes at 303 K were 12, 988.54 L/mol and 865.94 L/mol, respectively.The complexes were characterized using phase solubility diagrams, nuclear magnetic resonance (NMR) spectra and ultraviolet (UV) spectra.The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.关键词
β-环糊精/N-乙烯基吡咯烷酮/γ-射线辐照聚合/抑菌活性Key words
β-Cyclodextrin/N-Vinyl-2-pyrrolidone/γ-Ray initiated polymerization/Bacteriostatic activity引用本文复制引用
李咏富,哈益明,郭琴,李庆鹏..顺丁烯二酸β-环糊精酯-N-乙烯基吡咯烷酮水溶性聚合物的合成及其吸附疏水性药物的研究[J].分析化学,2017,45(6):874-882,9.基金项目
本文系贵州省特色农产品辐照保鲜技术服务企业行动计划项目(黔科合平台人才[2016]5712)、 贵州省特色农产品辐照保鲜与加工工程技术研究中心项目(黔科和人才平台[2016]5203号)"资助 （黔科合平台人才[2016]5712）
