口腔疾病防治2017，Vol.25Issue(6)：354-359,6.DOI:10.12016/j.issn.2096-1456.2017.06.003
白细胞介素-4-590C/T基因多态性与牙周炎易感性的Meta分析
Association between -590C/T polymorphisms of interleukin-4 gene and periodontitis: A meta-analysis
摘要
Abstract
Objective To evaluate the relationship between-590C/T polymorphisms of interleukin-4 gene and peri-odontitis by meta-analysis. Methods Databases including PubMed, EMbase, Web of Science, CBM, CNKI, Wanfang and VIP, were searched from their establishment to December 31, 2016. Only case-control studies on the association be-tween-590C/T polymorphisms of interleukin-4 gene and periodontitis were selected, and the references of those select-ed studies were searched by hand. Assessment and data extraction were conducted by 2 reviewers independently, and the meta-analysis was performed with the R 3.3.1 software. Results The meta-analysis showed that there was no asso-ciation between the IL-4-590C/T polymorphism and periodontitis susceptibility (T vs C:OR=1.19, 95%CI=0.81~1.76, P=0.37). Subgroup analysis showed that the IL-4-590 TT was associated with periodontitis in Caucasians (TT vs CT:OR=1.75, 95%CI=1.10~2.78, P=0.02), but no significant association in Asians (P=0.63). Meanwhile, IL-4 gene polymorphisms were not significantly associated with the susceptibility of chronic periodontitis (CP) or aggressive peri-odontitis (AgP) ( e. g. T vs C, CP: P=0.45; AgP: P=0.45). Conclusion Based on current evidence, the polymor-phisms of IL-4-590C/T are associated with the increased risk of periodontitis in Caucasians.关键词
牙周炎/白细胞介素-4/多态性/基因/Meta分析Key words
Periodontitis/Interleukin-4/Polymorphism/Gene/Meta-analysis分类
医药卫生引用本文复制引用
贾晓威,马艳,曾宪涛,袁亚娣,林英梅,邵军,张继斌..白细胞介素-4-590C/T基因多态性与牙周炎易感性的Meta分析[J].口腔疾病防治,2017,25(6):354-359,6.基金项目
广东省科技计划项目(2013B021800049) （2013B021800049）
广州市医药卫生科技项目(20141A010098) （20141A010098）
