口腔疾病防治2017，Vol.25Issue(6)：360-364,5.DOI:10.12016/j.issn.2096-1456.2017.06.004
牙周基础治疗对2型糖尿病伴慢性牙周炎患者龈沟液丝氨酸蛋白酶抑制剂和肿瘤坏死因子-α水平的影响
Effects of non-surgical periodontal treatment on level of vaspin and TNF-αin gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis
摘要
Abstract
Objective To investigate the changes of vaspin and TNF-αlevels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non-surgical periodontal treatment. Methods 60 subjects were divided into 4 groups: DM-CP group (patients with both T2DM and CP, n=15); CP group (CP patients without T2DM, n=15);DM group (T2DM patients without CP, n=15), and CTRL group (systemically and periodontally healthy individuals, n=15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non-surgical periodontal treatment. The levels of vaspin and TNF-αwere measured by ELISA. Results The lev-els of vaspin and TNF-αin CP group were significantly higher than those in CTRL group (P<0.05), while the levels of vaspin and TNF-αin CP group were significantly decreased after treatment (P<0.05). There was a statistically signifi-cant positive correlation between the total amount of vaspin and the total amount of TNF-α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05). Conclusion The results shows that vaspin and TNF-α are greatly de-creased in periodontitis after non-surgical periodontal treatment. It suggests that vaspin and TNF-α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.关键词
丝氨酸蛋白酶抑制剂/肿瘤坏死因子-α/龈沟液/牙周炎/糖尿病Key words
Visceral adipose tissue-derived serine protease inhibitor/Tumor necrosis factor-alpha/Gingival cre-vicular fluid/Periodontitis/Type 2 diabetes mellitus分类
医药卫生引用本文复制引用
王利宏,张文彪,习利军,包爱琴,黄世光..牙周基础治疗对2型糖尿病伴慢性牙周炎患者龈沟液丝氨酸蛋白酶抑制剂和肿瘤坏死因子-α水平的影响[J].口腔疾病防治,2017,25(6):360-364,5.基金项目
广东省深圳市福田区科技创新项目(FTWS20160031) （FTWS20160031）
