口腔疾病防治2017，Vol.25Issue(6)：394-397,4.DOI:10.12016/j.issn.2096-1456.2017.06.011
鼻咽癌放疗患者血清α2-巨球蛋白水平及临床意义
Serum levels of α2 - macroglobulin in patients with nasopharyngeal carcinoma radiotherapy and its clinical significance
摘要
Abstract
Objective To investigate the changes ofα2-macroglobulin in different stages of radiotherapy in patients with nasopharyngeal carcinoma, and to explore its feasibility as a marker of serum markers reflecting radiotherapy injury. Methods We collected the blood samples of 23 cases of newly diagnosed patients with nasopharyngeal carcinoma be-fore the simple radiotherapy, the 10, 20, 30 and 33 times after simple radiotherapy, detected theα2-macroglobulin lev-els. The difference among the five stages was analysed by paired t-test using SPSS17.0 software package. Results The serum level ofα2-macroglobulin elevated with the increase of number of radiotherapy. After 10 times'radiotherapy, the serum α2-MG concentration in patients with nasopharyngeal carcinoma was significantly higher than that before radio-therapy (12.04 ± 5.72 vs. 10.81 ± 5.38 U/L), the difference was statistically significant (t=4.818, P < 0.05). After 20 times'radiotherapy, the serumα2-MG concentration in patients with nasopharyngeal carcinoma was significantly higher than that before radiotherapy (12.26 ± 5.77 vs. 10.81 ± 5.38 U/L), and the difference was statistically significant (t=5.237, P<0.001). After 30 times'radiotherapy, the serumα2-MG concentration in patients with nasopharyngeal carci-noma was significantly higher than that before radiotherapy (12.91 ± 5.55 vs. 10.81 ± 5.38 U/L), the difference was sta-tistically significant (t=6.076, P < 0.05). At the end of radiotherapy, the serum α2-MG concentration in nasopharyn-geal carcinoma patients was significantly (13.43 ± 6.05 vs. 10.81 ± 5.38 U/L) higher than that before radiotherapy (t=5.189, P<0.05). Conclusion The serum level ofα2-macroglobulin changes with the radiotherapy, so it can be a se-rum marker reflecting the damage of maxilla induced by ionizing radiation.关键词
α2-巨球蛋白/鼻咽癌/放射治疗/颌骨/电离辐射Key words
α2-macroglobulin/Nasopharyngeal carcinoma/Radiotherapy/Jaw/Ionizing radiation分类
医药卫生引用本文复制引用
孙先阁,米姣平,房思炼,李惠玲,陈雪莹,葛雅平,梁侃,尧华昆..鼻咽癌放疗患者血清α2-巨球蛋白水平及临床意义[J].口腔疾病防治,2017,25(6):394-397,4.基金项目
珠海市科技计划项目(2015A0009) （2015A0009）
珠海市医学科研基金项目(2015J010) （2015J010）
