高电压技术2017，Vol.43Issue(6)：1925-1929,5.DOI:10.13336/j.1003-6520.hve.20170527024
正极性聚丙烯驻极体外静电场对5-氟尿嘧啶贴剂中药物释放的影响
Effect of External Electrostatic Field of Positive Polypropylene Electrets on Release of 5-fluorouracil from Adhesive Patch
摘要
Abstract
To study the effects of positive polypropylene(PP) electrets on cumulative release amounts of 5-fluorouracil (5-FU) from 5-FU patch and chemical enhancer (3％ azone) containing 5-FU patch,the ambient temperature corona charging technology was applied for preparation of 1 kV and 2 kV electret.For the preparation of 5-FU patch with electret,pressure-sensitive adhesive Eudragit E100 was used as matrix,tributyl citrate esters as plasticizer,and water-soluble azone as chemical permeation enhancer.The Franz diffusion pool and high performance liquid chromatograph were used to investigate the release rule of positive polarity electret electrostatic field to 5-FU in vitro.Results show that higher external electrostatic field of positive PP electrets with higher surface potential results in more drug release from 5-FU patches.The cumulative release amount of 5-FU from the 3％ azone containing 5-FU patches at 36 h under the action of 1 kV and 2 kV PP electrets are 2.53 and 3.10 times as compared with that of the 5-FU patch,respectively.Positive PP electrets can increase the drug release from the patch by changing the dielectric property and viscose force of the patch.The combination of electrets and 3％ azone can remarkably increase the release of 5-FU from its patches,which provides a new formulation and new strategy for treatment of hypertrophic scar.关键词
驻极体/5-氟尿嘧啶/压敏胶贴剂/氮酮/静电场/透皮给药Key words
electret/5-fluorouracil/pressure sensitive adhesive patches/azone/electrostatic field/transdermal drug delivery引用本文复制引用
徐立丽,黄平,苑旺,梁合鹃,崔黎丽,江键..正极性聚丙烯驻极体外静电场对5-氟尿嘧啶贴剂中药物释放的影响[J].高电压技术,2017,43(6):1925-1929,5.基金项目
国家自然科学基金(51477175).Project supported by National Natural Science Foundation of China (51477175). （51477175）
