摘要
Abstract
Objective To investigate the efficacy of atorvastatin combined with low molecular weight heparin in the treatment ofnephrotic syndrome.Methods 200 cases ofnephrotic syndrome treated at our hospital from January,2014 to December,2015 were divided into an observation group and a control group according to different treatment methods,100 cases for each group.In the addition of routine treatment,the control group was treated with low molecular weight heparin and the observation group with atorvastatin and low molecular weight heparin.The therapeutic effects of the two groups and the improvement of the blood lipid and renal function of the patients were observed.Results The serum albumin two group (Alb),24 h urinary protein (Pr),and blood urea nitrogen (BUN) were significantly improved in both group after treatment,.P ＜ 0.05 After treatment,Alb,Pr,and BUN were (26.97±3.65) g/L,(1.97±0.81) mmol/L,and (6.41±2.29) mmol/L in the observation group and were (23.76±3.31) g/L,(2.72±1.92) mmol/L,and (7.17±2.88) mmol/L in the control group,all P ＜ 0.05.The serum levels of total cholesterol (TC),three glycerol (TG),high density lipoprotein cholesterol (HDL-C),and low density lipoprotein cholesterol (LDL-C) were significantly improved in both groups after treatment,P ＜ 0.05.After treatment,the levels ofTC,TG,HDL-C,and LDL-C were (3.67±0.99)mmol/L,(1.25±0.77) mmol/L,(3.96±1.33) mmol/L,and (3.15±1.36) mmol/L in the observation group and were (6.12±1.25) mmol/L,(2.17±1.67) mmol/L,(3.31±1.25) mmol/L,and (5.33±2.91) mmol/L in the control group,all P＜0.05.The total efficacy was 87.0％ in the observation group and 68.0％ in the control group,P ＜ 0.05.No obvious adverse reactions occurred in both groups.Conclusions Atorvastatin combined with low molecular weight heparin in the treatment of nephrotic syndrome can effectively improve the blood lipid and renal function indicators.关键词
阿托伐他汀/低分子肝素/肾病综合征/血脂/肾功能Key words
Atorvastatin/Low molecular weight heparin/Nephrotic syndrome/Serum lipids/Renal function
