国际医药卫生导报2017，Vol.23Issue(12)：1891-1894,4.DOI:10.3760/cma.j.issn.1007-1245.2017.12.024
无创呼吸机在慢性阻塞性肺疾病合并呼吸衰竭患者中的应用效果及对炎症因子的影响
Application of noninvasive ventilator in patients with chronic obstructive pulmonary disease complicated with respiratory failure and its influence on inflammatory factors
贾钦尧 1宋珊 1韩美玲 1毛建 1陈绍平1
作者信息
摘要
Abstract
Objective To observe the clinical effect of noninvasive ventilator in patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure and its influence on inflammatory factors.Methods From December 2014 to October 2016,60 patients with COPD complicated with respiratory failure were randomly divided into control group (n=30) and observation group (n=30).The control group was treated with conventional methods,and the observation group was treated with non-invasive ventilator ventilation on the basis of the control group.IL-6 and TNF-α were detected by enzyme-linked immunosorbent assay,and CRP was detected by immunoturbidimetry.Compared clinical treatment effect and the impact on inflammatory factors of the two groups.Results The scores of mMRC and MVV in the observation group were lower than those in the control group 7 d after treatment (P＜0.05).The time of symptoms improvement and the length of stay in the observation group were shorter than those in the control group (P＜0.05).There were no statistically significant differences in the levels of IL-6,TNF-α,and CRP between the two groups be.fore treatment (P＞0.05);the levels of IL-6,TNF-α,and CRP in the observation group were lower than those in the control group 7 d after treatment (P＜0.05).There were no statistically significant differences in the levels ofpH,PaCO2,and PaO2 between the two groups before treatment (P＞0.05);7 d after treatment,the levels of pH and PaO2 in the observation group were higher than those in the control group (P＜0.05),the level of PaCO2 in the observation group was lower than that in the control group (P＜0.05).The rate of adverse reactions in the observation group was lower than that in the control group (6.67％ vs.20.00％,P＜0.05).Conclusion The combination of non-invasive ventilator in patients with chronic obstructive pulmonary disease and respiratory failure can improve the clinical therapeutic effect and reduce the levels of inflammatory factors,worthy of popularization and application.关键词
无创呼吸机/慢性阻塞性肺疾病/呼吸衰竭/炎症因子Key words
Non-invasive ventilator/Chronic obstructive pulmonary disease/Respiratory failure/Inflammatory factor引用本文复制引用
贾钦尧,宋珊,韩美玲,毛建,陈绍平..无创呼吸机在慢性阻塞性肺疾病合并呼吸衰竭患者中的应用效果及对炎症因子的影响[J].国际医药卫生导报,2017,23(12):1891-1894,4.
