广东药学院学报2017，Vol.33Issue(2)：235-240,6.DOI:10.16809/j.cnki.2096-3653.2016122701
HFE基因多态性与非酒精性脂肪肝病遗传易感性的Meta分析
Relationship between HFE polymorphisms and genetic susceptibility of nonalcoholic fatty liver disease:a Meta-analysis
摘要
Abstract
Objective To evaluate the correlation between the HFE polymorphisms (C282Y and H63D) and the susceptibility of nonalcoholic fatty liver disease (NAFLD).Methods The relevant literatures in PubMed,EMBASE,China National Knowledge Internet and Wanfang databases before Dec,2016 were collected.Odds ratio (OR) and 95% confidence intervals (95% CI) were applied as the effects estimates.The pooled analysis,sensitivity analysis and publication bias were performed in the software Stata V12.0.Results Seventeen studies with 2181 cases and 7921 controls were included in this Meta-analysis.The C282Y and H63D were both significantly with the risk of NAFLD,with the OR of 1.87 (95% CI=1.12-3.12) and 1.22 (95% CI=1.05-1.41) for the heterozygotes,respectively.Similarly,the OR were 1.95 (95% CI=1.14-3.31) and 1.24 (95% CI=1.07-1.43) for the dominant model,respectively.When performed the stratified analysis by the study populations,the significant genetic association of C282Y was only seen in Caucasian population,whereas this polymorphism did not exist in the Asian population.In the Caucasian and mixed populations,we also observed the significant association of H63D,whereas there was no significant association in the Asian population.No significant publication bias was found,and sensitivity analysis suggested the robust stability of the current results.Conclusion This Meta-analysis suggests that the variants of C282Y and H63D) in HFE gene could increase the risk of NAFLD,but the detrimental effect seems to be mainly existed in the Caucasian population.关键词
HFE/C282Y/H63D/基因多态性/非酒精性脂肪肝病/Meta分析Key words
HFE/C282Y/H63D/polymorphisms/nonalcoholic fatty liver disease/Meta-analysis分类
医药卫生引用本文复制引用
田娜娜,林欣琪,祁永芬,林子博,周新凤,刘丽..HFE基因多态性与非酒精性脂肪肝病遗传易感性的Meta分析[J].广东药学院学报,2017,33(2):235-240,6.基金项目
2015年广东省高等学校优秀青年教师培养计划项目(YQ2015098) （YQ2015098）
