国际妇产科学杂志2017，Vol.44Issue(3)：276-279,4.
外泌体在常见妇科恶性肿瘤诊治中的研究进展
Research Progress on Exosome in the Diagnosis and Treatment of Malignant Gynecologic Tumors
摘要
Abstract
Exosomes are nano vesicles with lipid bilayer structures which are derived from live cells. With various DNAs, RNAs and proteins inside, exosomes are widely involved in many physiological and pathological processes, such as information transfer and material exchange between cells. They can not only reflect the physiological and functional state of cells, but also play important roles in the regulation of tumor occurrence, development, invasion and metastasis. Exosomes derived from malignant tumor cells such as ovarian cancer, cervical cancer and endometrial cancer can be extracted from blood, vaginal lavage fluid, uterine lavage fluid and other body fluids with specificity by none-invasion procedure and can be used to extract tumor exosomes derived miRNAs and other biomarkers with fluid biopsy. Exosomes are recognized as novel means in the early screening, diagnosis and curative effectiveness evaluation of gynecologic malignancies. Tumor cells can acquire drug resistance by excreting chemotherapeutics via exosomes. Also, exosomes can be used as new routes of administration and improve the efficacy of anti-tumor drugs.关键词
生殖器肿瘤,女(雌)性/诊断/治疗/外泌体Key words
Genital neoplasms/Female/Diagnosis/Therapy/Exosome引用本文复制引用
吴若愚,贾翔,曹忆梦..外泌体在常见妇科恶性肿瘤诊治中的研究进展[J].国际妇产科学杂志,2017,44(3):276-279,4.基金项目
国家自然科学基金(81550008) （81550008）
