国际妇产科学杂志2017，Vol.44Issue(3)：280-283,4.
EpCAM在上皮性卵巢癌中的应用与研究进展
Application and Research Progress of EpCAM in Epithelial Ovarian Cancer
摘要
Abstract
Epithelial ovarian cancer is the most common gynecologic malignant tumor. It is difficult to diagnose early because of occult symptoms and the lack of effective screening tools. Recent studies have shown that epithelial cell adhesion molecules (EpCAM) can be used as biomarkers for early detection and prognosis of ovarian cancer. EpCAM is the first human tumor specific antigen recognized by monoclonal antibodies, high expression in epithelial ovarian cancer. EpCAM regulates the integrity of epithelial cells, mediates the adhesion and migration of ovarian cancer cells, and plays an important role in the invasion of ovarian cancer cells, and the expression of EpCAM is closely related to the prognosis of ovarian cancer patients. Currently, as a kind of important tumor marker, EpCAM has become a new target for immune therapy of ovarian tumor and an important index to evaluate the prognosis of patients with ovarian cancer. The high expression of EpCAM in epithelial ovarian cancer is of great significance for the treatment and prognosis of tumors. This article will review the application and research progress of EpCAM in epithelial ovarian cancer.关键词
上皮细胞黏附分子/细胞黏附分子/上皮性卵巢癌/卵巢肿瘤/治疗Key words
Epithelial cell adhesion molecule/Cell adhesion molecules/Epithelial ovarian cancer/Ovarian neoplasms/Therapy引用本文复制引用
张迪..EpCAM在上皮性卵巢癌中的应用与研究进展[J].国际妇产科学杂志,2017,44(3):280-283,4.基金项目
国家自然科学基金(81372787,81072136) （81372787,81072136）
