神经损伤与功能重建2017，Vol.12Issue(3)：221-224,4.DOI:10.16780/j.cnki.sjssgncj.2017.03.011
miR-132在神经胶质瘤中表达及临床意义
The Expression and Clinical Significance of miR-132 in Glioma
武丽芳 1杜剑峰1
作者信息
- 1. 延安大学附属医院神经内科 陕西716000
- 折叠
摘要
Abstract
Objective:To investigate the expression and clinical significance of microRNA (miR-132) in patients with glioma.Methods:One hundred thirty-five cases with glioma (glioma group) and 53 cases of normal brain tissues (control group) were collected.Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the miR-132 expression in 2 groups.The clinic pathological characteristics ofmiR-132 expression were further analyzed.A receiver operating characteristic (ROC) curve was constructed to determine the diagnostic value of miR-132.Results:miR-132 expression was significantly up-regulated in the glioma group compared with that in the normal group (P＜0.05).There was significant differences between KPS score,extent of resection and WHO grade in terms of miR-132 expression (P＜0.05).The area under the ROC curve was 0.856 (P＜0.001),the sensitivity was 52.7％,the specificity was 86.6％ and the index of Youden was 0.465.The overall survival time and progression free survival in miR-132 high expression and low expression sub-groups were statistically significant (P＜0.01).Conclusion:miR-132 may be involved in carcinogenesis of glioma,which may be a new biomarker for diagnosis and treatment.关键词
miR-132/神经胶质瘤/ROC曲线/临床病理特征/生物标记物Key words
miR-132/glioma/ROC curve/clinicopathological/biomarker分类
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武丽芳,杜剑峰..miR-132在神经胶质瘤中表达及临床意义[J].神经损伤与功能重建,2017,12(3):221-224,4.
