广西医学2017，Vol.39Issue(6)：757-760,4.DOI:10.11675/j.issn.0253-4304.2017.06.01
地尔硫(草卓)治疗急性非ST段抬高型心肌梗死合并心力衰竭的临床效果
Clinical efficacy of diltiazem in treatment of acute non-ST-segment elevation myocardial infarction complicated with heart failure
摘要
Abstract
Objective To investigate the efficacy and safety of diltiazem in the treatment of acute non-ST-segment elevation myocardial infarction(ANSTEMI) complicated with heart failure.Methods A total of 80 patients with ANSTEMI complicated with heart failure were randomly divided into diltiazem group and control group,with 40 cases in each group.The control group received conventional treatment,and the diltiazem group was intravenously administered diltiazem on the basis of the conventional treatment.The relief of angina pectoris,elevation of ST segment,improvement of heart function and the incidence of adverse effects were compared between the two groups.Results The relief of angina pectoris and the improvement of ischemic ST segment in the diltiazem group were superior to those in the control group(P<0.05).After treatment,SBP,DBP and HR decreased in both groups(P<0.05),and HR in the diltiazem group was significantly lower than that in the control group(P<0.05),but there were no significant differences in the SBP or DBP between the two groups(P>0.05).After treatment,N-terminal pro-B-type natriuretic peptide(NT-proBNP) decreased and left ventricular ejection fraction(LVEF) increased in both groups(P<0.05),but there were no significant differences in the NT-proBNP or LVEF between the two groups(P>0.05).There was no significant difference in the left ventricular end diastolic dimension between the two groups before and after treatment(P>0.05).No significant difference was fund in the incidence of adverse effects between the two groups(P>0.05).Conclusion For the patients with ANSTEMI complicated with heart failure,the intravenous administration of diltiazem can significantly relieve angina pectoris but does not exacerbate heart failure,and is significantly effective,safe and reliable.关键词
急性非ST段抬高型心肌梗死/心力衰竭/地尔硫(草卓)Key words
Acute non-ST-segment elevation myocardial infarction/Heart failure/Diltiazem分类
医药卫生引用本文复制引用
杨礼文,夏豪,田国卫,郑雅格..地尔硫(草卓)治疗急性非ST段抬高型心肌梗死合并心力衰竭的临床效果[J].广西医学,2017,39(6):757-760,4.基金项目
国家自然科学基金(81270184) （81270184）
